Body fat and other metabolic effects of atazanavir and efavirenz, each administered in combination with zidovudine plus lamivudine, in antiretroviral-naive HIV-infected patients

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dc.contributor.authorJemsek, JG
dc.contributor.authorArathoon, E
dc.contributor.authorArlotti, M
dc.contributor.authorPerez, C
dc.contributor.authorSosa, N
dc.contributor.authorPokrovskiy, V
dc.contributor.authorThiry, A
dc.contributor.authorSoccodato, M
dc.contributor.authorNoor, MA
dc.contributor.authorGiordano, M
dc.date.accessioned2024-01-10T13:11:30Z
dc.date.available2024-01-10T13:11:30Z
dc.date.issued2006
dc.description.abstractBackground. Protease inhibitor treatment of human immunodeficiency virus (HIV)-infected individuals has been linked to the development of lipodystrophy. The effects of atazanavir on body fat distribution and related metabolic parameters were examined in antiretroviral-naive patients.
dc.description.abstractMethods. HIV-positive patients with CD4 cell counts >= 100 cells/mm(3) were randomized to 1 of 2 treatment arms: (1) atazanavir, 400 mg given once daily, plus efavirenz placebo; or (2) efavirenz, 600 mg given once daily, plus atazanavir placebo; each drug was administered with fixed-dose zidovudine (300 mg) and lamivudine (150 mg) given twice daily, and patients were treated for at least 48 weeks. Fat distribution measurements (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT], and total adipose tissue [TAT], as measured by computed tomography; and appendicular fat, truncal fat, and total fat levels, as measured by dual-energy X-ray absorptiometry), metabolic measurements (cholesterol and fasting triglyceride levels), and measurements of insulin resistance (fasting glucose and fasting insulin levels) were made at baseline and at week 48 of treatment for a subgroup of 111 atazanavir recipients and 100 efavirenz recipients.
dc.description.abstractResults. Atazanavir and efavirenz treatments resulted in minimal to modest increases in fat accumulation, as measured by VAT, SAT, TAT, appendicular fat, truncal fat, and total fat levels; results were comparable in both arms. In addition, atazanavir was associated with none of the metabolic abnormalities seen with many other protease inhibitors.
dc.description.abstractConclusions. Use of atazanavir for 48 weeks neither resulted in abnormal fat redistribution in antiretroviral-naive patients nor induced other metabolic disturbances commonly associated with HIV-related lipodystrophy. Longer-term assessments (e.g., at 96 weeks) will be important to confirm these findings.
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1086/498505
dc.identifier.eissn1537-6591
dc.identifier.issn1058-4838
dc.identifier.pubmedidMEDLINE:16355341
dc.identifier.urihttps://doi.org/10.1086/498505
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78053
dc.identifier.wosidWOS:000233981800019
dc.information.autorucMedicina;Pérez C;S/I;66650
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final280
dc.pagina.inicio273
dc.publisherOXFORD UNIV PRESS INC
dc.revistaCLINICAL INFECTIOUS DISEASES
dc.rightsacceso restringido
dc.subjectPROTEASE INHIBITORS
dc.subjectHIV-1-INFECTED PATIENTS
dc.subjectINSULIN-RESISTANCE
dc.subjectRISK-FACTORS
dc.subjectLIPODYSTROPHY
dc.subjectTHERAPY
dc.subjectHYPERLIPIDEMIA
dc.subjectGLUCOSE
dc.subjectDIFFERENTIATION
dc.subjectDIAGNOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBody fat and other metabolic effects of atazanavir and efavirenz, each administered in combination with zidovudine plus lamivudine, in antiretroviral-naive HIV-infected patients
dc.typeartículo
dc.volumen42
sipa.codpersvinculados66650
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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