Behavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron

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dc.contributor.authorLacassie, Hector J.
dc.contributor.authorSchultz, John R.
dc.contributor.authorCummings, Thomas J.
dc.contributor.authorMorris, Richard
dc.contributor.authorTrasti, Scott L.
dc.contributor.authorReynolds, James D.
dc.date.accessioned2024-01-10T13:11:26Z
dc.date.available2024-01-10T13:11:26Z
dc.date.issued2006
dc.description.abstractIntrathecal injection of ondansetron has the potential to reduce opioid-related side-effects. The aim of the present study was to determine whether this route of administration produces neuraxial injury.
dc.description.abstractAdult, non-pregnant female New Zealand white rabbits received a single bolus injection of a low (40 mu g) or high (4.0 mg) dose of ondansetron into the intrathecal space between the 4th and 5th lumbar vertebrae. In some cases, ondansetron was coadministered with morphine (5 mu g/kg). Control animals received a bolus injection of normal saline. Behavioural assessments were conducted at 1 and 24 h to determine overt changes in arousal and mobility, followed by histological evaluation of the excised spinal cord.
dc.description.abstractOf 45 animals investigated, 10 rabbits exhibited modest behavioural evidence of spinal injury, the incidence of which was equally distributed between the treatment groups. Haematoxylin and eosin, along with HAM56, staining of cross-sections of the cervical, thoracic and upper and lower lumbar areas revealed mild signs of inflammation. This, too, was equally distributed between the treatment groups, suggesting that any observed neuraxial injury was the result of needle trauma and not ondansetron neurotoxicity.
dc.description.abstractCollectively, these negative findings support conducting further experiments to fully assess the clinical usefulness of intrathecal ondansetron administration.
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1440-1681.2006.04442.x
dc.identifier.issn1440-1681
dc.identifier.pubmedidMEDLINE:16922809
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2006.04442.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78045
dc.identifier.wosidWOS:000239659300006
dc.information.autorucMedicina;Lacassie HJ;S/I;68956
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final801
dc.pagina.inicio798
dc.publisherWILEY
dc.revistaCLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectneurotoxicity
dc.subjectondansetron
dc.subjectsubarachnoid
dc.subjectMIDAZOLAM
dc.subjectNEUROTOXICITY
dc.subjectMORPHINE
dc.titleBehavioural testing and histological assessments of rabbit spinal cord following intrathecal administration of ondansetron
dc.typeartículo
dc.volumen33
sipa.codpersvinculados68956
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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