Mismatch repair expression in testicular cancer predicts recurrence and survival

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dc.catalogadordfo
dc.contributor.authorVelasco Palma, Alfredo Alejandro
dc.contributor.authorCorvalán Rodríguez, Alejandro
dc.contributor.authorWistuba, Ignacio I.
dc.contributor.authorRiquelme, Erick
dc.contributor.authorChuaqui, Rodrigo
dc.contributor.authorMajerson Grinberg, Alejandro
dc.contributor.authorLeach, Fredrick S.
dc.date.accessioned2024-07-18T14:49:08Z
dc.date.available2024-07-18T14:49:08Z
dc.date.issued2008
dc.description.abstractWe investigated mismatch repair (MMR) gene expression in testicular cancer as a molecular marker for clinical outcome (recurrence, response to chemotherapy and death) using protein expression and specific genetic alterations associated with the presence or absence of MMR activity. One hundred sixty-two cases of paraffin-embedded testis cancer specimens were subjected to immunohistochemical analysis using monoclonal antibody for MLH1 and MSH2 MMR proteins and genetic analysis using specific polymorphic markers. The degree of MMR immunoreactivity and genetic instability in the form of loss of heterozygosity (LOH) and/or microsatellite instability (MSI) were determined by comparing matched normal and tumor tissue. The degree of immunohistochemical staining for MMR expression was associated with a shorter time to tumor recurrence, resistance to chemotherapy and death. Furthermore, clinical relapse and cancer specific death was also associated with tumors exhibiting a high degree of MSI, p = 0.01 and 0.04, respectively. In contrast, LOH was not associated with recurrence, resistance to chemotherapy or death. Therefore, MMR expression defines testis cancers with distinct molecular properties and clinical behavior, such that tumors with decreased MMR immunostaining and/or increased frequency of MSI have a shorter time to recurrence and death despite chemotherapy. (c) 2007 Wiley-Liss, Inc.
dc.description.funderNCI NIH HHS
dc.description.funderNATIONAL CANCER INSTITUTE
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ijc.23291
dc.identifier.issn0020-7136
dc.identifier.pubmedidMEDLINE:18076065
dc.identifier.urihttps://doi.org/10.1002/ijc.23291
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87108
dc.identifier.wosidWOS:000254068300014
dc.information.autorucEscuela de Medicina; Velasco Palma Alfredo Alejandro; S/I; 58191
dc.information.autorucEscuela de Medicina; Corvalan Rodriguez Alejandro; 0000-0001-5492-3853; 63885
dc.information.autorucEscuela de Medicina; Majerson Grinberg Alejandro; 0000-0001-5411-8213; 148013
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1777
dc.pagina.inicio1774
dc.revistaInternational Journal of Cancer
dc.rightsacceso restringido
dc.subjectMismatch repair
dc.subjecthMSH2
dc.subjectTesticular cancer
dc.subjectMicrosatellite instability
dc.titleMismatch repair expression in testicular cancer predicts recurrence and survival
dc.typeartículo
dc.volumen122
sipa.codpersvinculados75420
sipa.codpersvinculados58191
sipa.codpersvinculados63885
sipa.codpersvinculados148013
sipa.trazabilidadWOS;05-06-2021
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