Global prevalence and molecular characterization of extended-spectrum beta-lactamase producing-Escherichia coli in dogs and cats - A scoping review and meta-analysis

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dc.contributor.authorSalgado Caxito, Marilia
dc.contributor.authorBenavides, Julio A.
dc.contributor.authorAdell, Aiko D.
dc.contributor.authorPaes, Antonio Carlos
dc.contributor.authorMoreno Switt, Andrea, I
dc.date.accessioned2024-01-10T14:23:31Z
dc.date.available2024-01-10T14:23:31Z
dc.date.issued2021
dc.description.abstractAntimicrobial resistance (AMR) represents a major threat to human and animal health. Part of the AMR dimension is the circulation of extended-spectrum ?-lactamases producing-Escherichia coli (ESBL-E. coli), which is now commonly reported among companion animals. However, the global perspective of the prevalence and population structure of ESBL-E. coli circulating in dogs and cats has not been estimated limiting our understanding of their role in the dissemination of ESBL-E. coli. The aim of this study was to compare the prevalence of ESBL-E. coli between dogs and cats and across countries through meta-analysis. We also performed a scoping review to summarize the current knowledge on ESBL genes and E. coli clones circulating among companion animals. A total of 128 studies published in PubMed, Web of Science, and Scopus up to April 2020 were selected and contained information on prevalence and/or molecular characterization of ESBL genes and ESBL-E. coli clones. Our review shows an increase in the number of publications between 2000 and 2019, concentrated mainly in Europe. Prevalence varied across continents, ranging from 0.63% (Oceania) to 16.56% (Africa) in dogs and from 0% (Oceania) to 16.82% (Asia) in cats. Although there were twice as many studies reporting prevalence on dogs (n = 61) than on cats (n = 32), and only 9 studies focused exclusively on cats, our meta-analysis showed no difference in the global prevalence of ESBL-E. coli between dogs (6.87% [95% CI: 4.46?10.45%]) and cats (5.04% [95% CI: 2.42?10.22%]). A considerable diversity of ESBL genes (n = 60) and sequence types (ST) (n = 171) were recovered from companion animals. ESBL-E. coli encoded by CTX-M-15 (67.5%, 77/114) and SHV-12 (21.9%, 25/114), along with resistant strains of ST38 (22.7%, 15/66) and ST131 (50%, 33/66) were widespread and detected in all continents. While presence of ESBL-E. coli is widespread, the drivers influencing the observed ESBL-E. coli prevalence and the clinical relevance in veterinary medicine and public health along with economic impact of ESBL-E. coli infections among companion animals need to be further investigated.
dc.description.funderCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES)
dc.description.funderFONDECYT
dc.description.funderANID Millennium Science Initiative/Millennium Initiative for Collaborative Research on Bacterial Resistance, MICROB-R
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.onehlt.2021.100236
dc.identifier.eissn2352-7714
dc.identifier.pubmedidMEDLINE:33889706
dc.identifier.urihttps://doi.org/10.1016/j.onehlt.2021.100236
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80106
dc.identifier.wosidWOS:000644329100007
dc.information.autorucFacultad de Agronomía e Ingeniería Forestal; Moreno Switt, Andrea Isabel; S/I; 1147061
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherELSEVIER
dc.rightsacceso abierto
dc.subjectAntimicrobial resistance
dc.subjectCompanion animals
dc.subjectESBL
dc.subjectPets
dc.subjectResistance genes
dc.subjectWorldwide
dc.subjectMEDIATED QUINOLONE RESISTANCE
dc.subjectCOMPANION ANIMALS
dc.subjectRISK-FACTORS
dc.subjectCTX-M
dc.subjectANTIMICROBIAL RESISTANCE
dc.subjectCEPHALOSPORIN RESISTANCE
dc.subjectFECAL COLONIZATION
dc.subjectINCFII PLASMIDS
dc.subject1ST DETECTION
dc.subjectHEALTHY DOGS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlobal prevalence and molecular characterization of extended-spectrum beta-lactamase producing-Escherichia coli in dogs and cats - A scoping review and meta-analysis
dc.typeartículo de revisión
dc.volumen12
sipa.codpersvinculados1147061
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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