The asthma predictive index as a surrogate diagnostic tool in preschoolers: Analysis of a longitudinal birth cohort

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dc.catalogadorjca
dc.contributor.authorCastro Rodriguez, Jose A.
dc.contributor.authorForno, Erick
dc.contributor.authorPadilla, Oslando
dc.contributor.authorCasanello, Paola
dc.contributor.authorKrause, Bernardo J.
dc.contributor.authorBorzutzky Schachter, Arturo
dc.date.accessioned2023-01-30T16:08:09Z
dc.date.available2023-01-30T16:08:09Z
dc.date.issued2021
dc.description.abstractDiagnosing asthma in preschool children remains an unsolved challenge, at a time when early identification would allow for better education and treatment to prevent morbidity and lung function deterioration. Objective To evaluate if the asthma predictive index (API) can be used as surrogate for asthma diagnosis in preschoolers. Methods Birth cohort of 339 pregnant women enrolled at delivery and their offspring, who were followed for atopy, wheezing, and other respiratory illnesses through 30 months of age. The API was determined at 30 months of age by the researchers; and examined its association with physician-diagnosed asthma during the first 30 months, made independently by the primary care physician not involved in the study. Results Among 307 offspring with complete follow-up, 44 (14.3%) were API+. Maternal body mass index, maternal education, past oral contraceptive use, birthweight, placenta weight, age of daycare at 12 m, gastroesophageal reflux disease at 12 m, acute otitis media at 18 m, bronchiolitis, croup and pneumonia, cord blood adiponectin were all associated with API+. In the multivariable analysis, API+ was associated with almost sixfold odds of asthma diagnosis (adjusted OR = 5.7, 95% CI [2.6-12.3]), after adjusting for the relevant covariates above including respiratory infections like bronchiolitis and pneumonia. The API sensitivity was 48%, specificity 92%, 61% PPV, 88% NPV, 6.4 LR+, 0.56 LR-, 0.84 diagnosis accuracy. The adjusted odds for asthma was 11.4. Conclusions This longitudinal birth cohort suggests, for first time, that API (a structured definition for asthma), could be used as a diagnostic tool, not only as a prognostic tool, in toddlers and preschoolers.
dc.description.funderFoundation for the National Institutes of Health
dc.description.funderConsejo Nacional de Innovacion, Ciencia y Tecnologia
dc.fechaingreso.objetodigital2023-01-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ppul.25592
dc.identifier.eissn1099-0496
dc.identifier.issn8755-6863
dc.identifier.pubmedidMEDLINE:34320686
dc.identifier.scopusidSCOPUS_ID:85111539925
dc.identifier.urihttps://doi.org/10.1002/ppul.25592
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66459
dc.identifier.wosidWOS:000678243900001
dc.information.autorucEscuela de Medicina; Borzutzky Schachter Arturo Jose; 0000-0002-7904-262X; 5897
dc.issue.numero10
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final3188
dc.pagina.inicio3183
dc.publisherWILEY
dc.revistaPEDIATRIC PULMONOLOGY
dc.rightsacceso abierto
dc.subjectasthma
dc.subjectasthma predictive index
dc.subjectdiagnosis
dc.subjectpreschoolers
dc.subjectrecurrent wheezing
dc.subjectCHILDHOOD ASTHMA
dc.subjectCHILDREN
dc.subjectRISK
dc.subjectAGE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe asthma predictive index as a surrogate diagnostic tool in preschoolers: Analysis of a longitudinal birth cohort
dc.typeartículo
dc.volumen56
sipa.codpersvinculados5897
sipa.indexWoS
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