Heparin activates Wnt signaling for neuronal morphogenesis

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dc.contributor.authorColombres, Marcela
dc.contributor.authorHenriquez, Juan Pablo
dc.contributor.authorReig, German F.
dc.contributor.authorScheu, Jessica
dc.contributor.authorCalderon, Rosario
dc.contributor.authorAlvarez, Alejandra
dc.contributor.authorBrandan, Enrique
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2024-01-10T12:39:21Z
dc.date.available2024-01-10T12:39:21Z
dc.date.issued2008
dc.description.abstractWrit factors are secreted ligands that affect different aspects of the nervous system behavior like neurodevelopment, synaptogenesis and neurodegeneration. In different model systems, Wnt signaling has been demonstrated to be regulated by heparan sulfate proteoglycans (HSPGs). Whether HSPGs modulate Writ signaling in the context of neuronal behavior is currently unknown. Here we demonstrate that activation of Wnt signaling with the endogenous ligand Wnt-7a results in an increased of neurite outgrowth in the neuroblastoma N2a cell line. Interestingly, heparin induces glycogen synthase kinase-3 beta (GSK-3 beta) inhibition, beta-catenin stabilization and morphological differentiation in both N2a cells and in rat primary hippocampal neuronal cultures. We also show that heparin modulates Wnt-3a-induced stabilization of beta-catenin. Several extracellular matrix and membrane-attached HSPGs were found to be expressed in both in vitro neuronal models. Changes in the expression of specific HSPGs were observed upon differentiation of N2a cells. Taken together, our findings suggest that HSPGs may modulate canonical Writ signaling for neuronal morphogenesis.
dc.fechaingreso.objetodigital2024-04-27
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/jcp.21465
dc.identifier.eissn1097-4652
dc.identifier.issn0021-9541
dc.identifier.pubmedidMEDLINE:18449906
dc.identifier.urihttps://doi.org/10.1002/jcp.21465
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77179
dc.identifier.wosidWOS:000258273400027
dc.information.autorucCiencias Biológicas;Brandan E;S/I;52075
dc.information.autorucCiencias Biológicas;Calderón R;S/I;12795
dc.information.autorucCiencias Biológicas;Colombres M;S/I;19114
dc.information.autorucCiencias Biológicas;Henríquez J;S/I;5706
dc.information.autorucCiencias Biológicas;Inestrosa NC;S/I;99331
dc.information.autorucCiencias Biológicas;Reig G;S/I;1002440
dc.information.autorucCiencias Biológicas;Scheu J;S/I;11439
dc.information.autorucCiencias Biológicas;Álvarez A;S/I;83681
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final815
dc.pagina.inicio805
dc.publisherWILEY
dc.revistaJOURNAL OF CELLULAR PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectBETA-PEPTIDE NEUROTOXICITY
dc.subjectNEURITE OUTGROWTH
dc.subjectSULFATE PROTEOGLYCANS
dc.subjectNERVOUS-SYSTEM
dc.subjectHIPPOCAMPAL-NEURONS
dc.subjectSKELETAL-MUSCLE
dc.subjectAXON GUIDANCE
dc.subjectMOLECULAR-CLONING
dc.subjectN-SYNDECAN
dc.subjectPATHWAY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHeparin activates Wnt signaling for neuronal morphogenesis
dc.typeartículo
dc.volumen216
sipa.codpersvinculados52075
sipa.codpersvinculados12795
sipa.codpersvinculados19114
sipa.codpersvinculados5706
sipa.codpersvinculados99331
sipa.codpersvinculados1002440
sipa.codpersvinculados11439
sipa.codpersvinculados83681
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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