The chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study

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dc.contributor.authorMontes de Oca, Maria
dc.contributor.authorHalbert, Ronald J.
dc.contributor.authorVictorina Lopez, Maria
dc.contributor.authorPerez Padilla, Rogelio
dc.contributor.authorTalamo, Carlos
dc.contributor.authorMoreno, Dolores
dc.contributor.authorMuino, Adrianna
dc.contributor.authorJardim, Jose Roberto B.
dc.contributor.authorValdivia, Gonzalo
dc.contributor.authorPertuze, Julio
dc.contributor.authorMenezes, Ana Maria B.
dc.date.accessioned2024-01-10T14:21:55Z
dc.date.available2024-01-10T14:21:55Z
dc.date.issued2012
dc.description.abstractLittle information exists regarding the epidemiology of the chronic bronchitis phenotype in unselected chronic obstructive pulmonary disease (COPD) populations. We examined the prevalence of the chronic bronchitis phenotype in COPD and non-COPD subjects from the PLATINO study, and investigated how it is associated with important outcomes.
dc.description.abstractPost-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.70 was used to define COPD. Chronic bronchitis was defined as phlegm on most days, at least 3 months per year for >= 2 yrs. We also analysed another definition: cough and phlegm on most days, at least 3 months per year for >= 2 yrs.
dc.description.abstractSpirometry was performed in 5,314 subjects (759 with and 4,554 without COPD). The proportion of subjects with and without COPD with chronic bronchitis defined as phlegm on most days, at least 3 months per year for >= 2 yrs was 14.4 and 6.2%, respectively. Using the other definition the prevalence was lower: 7.4% with and 2.5% without COPD. Among subjects with COPD, those with chronic bronchitis had worse lung function and general health status, and had more respiratory symptoms, physical activity limitation and exacerbations.
dc.description.abstractOur study helps to understand the prevalence of the chronic bronchitis phenotype in an unselected COPD population at a particular time-point and suggests that chronic bronchitis in COPD is possibly associated with worse outcomes.
dc.description.funderBoehringer Ingelheim GmbH
dc.description.funderAsociacion Latinoamericana de Torax
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1183/09031936.00141611
dc.identifier.issn0903-1936
dc.identifier.pubmedidMEDLINE:22282547
dc.identifier.urihttps://doi.org/10.1183/09031936.00141611
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79817
dc.identifier.wosidWOS:000307287500008
dc.information.autorucMedicina;Pertuze J;S/I;99166
dc.information.autorucMedicina;Valdivia G ;S/I;57007
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final36
dc.pagina.inicio28
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.revistaEUROPEAN RESPIRATORY JOURNAL
dc.rightsacceso restringido
dc.subjectAsthma
dc.subjectchronic cough
dc.subjectchronic obstructive pulmonary disease
dc.subjectepidemiology
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectLATIN-AMERICAN CITIES
dc.subjectAIR-FLOW OBSTRUCTION
dc.subjectCHRONIC MUCUS HYPERSECRETION
dc.subjectLUNG-FUNCTION
dc.subjectRESPIRATORY SYMPTOMS
dc.subjectRISK-FACTORS
dc.subjectMORTALITY
dc.subjectCOHORT
dc.subjectPREVALENCE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe chronic bronchitis phenotype in subjects with and without COPD: the PLATINO study
dc.typeartículo
dc.volumen40
sipa.codpersvinculados99166
sipa.codpersvinculados57007
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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