Impact of cigarette smoking on the gastrointestinal tract inflammation: Opposing effects in Crohn\'s disease and ulcerative colitis

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dc.catalogadorgjm
dc.contributor.authorBerkowitz Fiebich, Loni
dc.contributor.authorSchultz Lombardic, Bárbara M.
dc.contributor.authorSalazar Tapia, Geraldyne Alessandra
dc.contributor.authorPardo Roa, Catalina
dc.contributor.authorSebastián Quijada, Valentina Pilar
dc.contributor.authorÁlvarez Lobos, Manuel
dc.contributor.authorBueno Ramírez, Susan
dc.date.accessioned2024-01-30T15:23:30Z
dc.date.available2024-01-30T15:23:30Z
dc.date.issued2018
dc.description.abstractCigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer, Crohn's disease (CD), and several cancers. The mechanisms proposed to explain the role of smoking in these disorders include mucosal damage, changes in gut irrigation, and impaired mucosal immune response. Paradoxically, cigarette smoking is a protective factor for the development and progression of ulcerative colitis (UC). UC and CD represent the two most important conditions of inflammatory bowel diseases, and share several clinical features. The opposite effects of smoking on these two conditions have been a topic of great interest in the last 30 years, and has not yet been clarified. In this review, we summarize the most important and well-understood effects of smoking in the gastrointestinal tract; and particularly, in intestinal inflammation, discussing available studies that have addressed the causes that would explain the opposite effects of smoking in CD and UC.
dc.fechaingreso.objetodigital2024-05-08
dc.fuente.origenORCID
dc.identifier.doi10.3389/fimmu.2018.00074
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-85041589534&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81063
dc.identifier.wosidWOS:000423556600001
dc.information.autorucFacultad de Ciencias Biológicas; Berkowitz Fiebich, Loni; S/I; 172010
dc.information.autorucFacultad de Ciencias Biológicas; Schultz Lombardic, Bárbara M.; 0000-0002-6201-6978; 186964
dc.information.autorucFacultad de Ciencias Biológicas; Salazar Tapia, Geraldyne Alessandra; S/I; 1044678
dc.information.autorucFacultad de Ciencias Biológicas; Pardo Roa, Catalina; 0000-0002-5409-225X; 225251
dc.information.autorucFacultad de Ciencias Biológicas; Sebastián Quijada, Valentina Pilar; S/I; 171925
dc.information.autorucEscuela de Medicina; Álvarez Lobos, Manuel; S/I; 6131
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subjectCigarette smoking
dc.subjectCrohn's disease
dc.subjectGastrointestinal inflammation
dc.subjectInflammatory bowel disease
dc.subjectUlcerative colitis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImpact of cigarette smoking on the gastrointestinal tract inflammation: Opposing effects in Crohn\'s disease and ulcerative colitis
dc.typeartículo
sipa.codpersvinculados172010
sipa.codpersvinculados186964
sipa.codpersvinculados1044678
sipa.codpersvinculados225251
sipa.codpersvinculados171925
sipa.codpersvinculados6131
sipa.codpersvinculados113541
sipa.trazabilidadORCID;2024-01-15
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