Population-based prevalence and age distribution of human papillomavirus among women in Santiago, Chile

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dc.contributor.authorFerreccio, C
dc.contributor.authorPrado, RB
dc.contributor.authorLuzoro, AV
dc.contributor.authorAmpuero, SL
dc.contributor.authorSnijders, PJF
dc.contributor.authorMeijer, CJLM
dc.contributor.authorVaccarella, SV
dc.contributor.authorJara, AT
dc.contributor.authorPuschel, KI
dc.contributor.authorRobles, SC
dc.contributor.authorHerrero, R
dc.contributor.authorFranceschi, SF
dc.contributor.authorOjeda, JM
dc.date.accessioned2024-01-10T12:41:35Z
dc.date.available2024-01-10T12:41:35Z
dc.date.issued2004
dc.description.abstractMore than 18 types of human papillomavirus (HPV) are associated with cervical cancer, the relative importance of the HPV types may vary in different populations.
dc.description.abstractObjective: To investigate the types of HPV, age distribution, and risk factors for HPV infection in women from Santiago, Chile.
dc.description.abstractMethods: We interviewed and obtained two cervical specimens from a population-based random sample of 1,038 sexually active women (age range, 15-69 years). Specimens were tested for the presence of HPV DNA using a GP5+/6+ primer-mediated PCR and for cervical cytologic abnormalities by Papanicolaou smears.
dc.description.abstractResults: 122 women tested positive for HPV DNA, 87 with high risk types (HR), and 35 with low risks (LR) only. Standardized prevalence of HPV DNA was 14.0% [95% confidence interval (95% CI), 11.5-16.4]. HR HPV by age showed a J reverse curve, whereas LR HPV showed a U curve, both statistically significant in comparison with no effect or with a linear effect. We found 34 HPV types (13 HR and 21 LR); HPV 16, 56, 31, 58, 59, 18, and 52 accounted for 75.4% of HR infections. Thirty-four (3.6%) women had cytologic lesions. Main risk factor for HPV and for cytologic abnormalities was number of lifetime sexual partners, odds ratios for greater than or equal to 3 versus 1 were 2.8 (95% CI, 1.6-5.0) and 3.8 (95% CI, 1.3-11.4), respectively.
dc.description.abstractConclusions: LR HPV presented a clear bimodal age pattern; HR HPV presented a J reverse curve. HPV prevalence was similar to that described in most Latin American countries.
dc.fechaingreso.objetodigital2024-06-14
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1158/1055-9965.2271.13.12
dc.identifier.eissn1538-7755
dc.identifier.issn1055-9965
dc.identifier.pubmedidMEDLINE:15598792
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77432
dc.identifier.wosidWOS:000226077100043
dc.information.autorucMedicina;Ferreccio F;S/I;99684
dc.information.autorucMedicina;Puschel K;S/I;83957
dc.issue.numero12
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2276
dc.pagina.inicio2271
dc.publisherAMER ASSOC CANCER RESEARCH
dc.revistaCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
dc.rightsacceso restringido
dc.subjectHPV INFECTION
dc.subjectHIGH-RISK
dc.subjectDETERMINANTS
dc.subjectGENOTYPES
dc.subjectPCR
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titlePopulation-based prevalence and age distribution of human papillomavirus among women in Santiago, Chile
dc.typeartículo
dc.volumen13
sipa.codpersvinculados99684
sipa.codpersvinculados83957
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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