A simple analytical model for a fast 3D assessment of peripheral photon dose during coplanar isocentric photon radiotherapy

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dc.article.number872752
dc.contributor.authorSánchez Nieto, Beatriz
dc.contributor.authorLópez Martínez, Ignacio N.
dc.contributor.authorRodríguez Mongua, José Luis
dc.contributor.authorEspinoza Bornscheuer, Ignacio Guillermo
dc.date.accessioned2023-01-16T18:43:46Z
dc.date.available2023-01-16T18:43:46Z
dc.date.issued2022
dc.description.abstractConsidering that cancer survival rates have been growing and that nearly two-thirds of those survivors were exposed to clinical radiation during its treatment, the study of long-term radiation effects, especially secondary cancer induction, has become increasingly important. To correctly assess this risk, knowing the dose to out-of-field organs is essential. As it has been reported, commercial treatment planning systems do not accurately calculate the dose far away from the border of the field; analytical dose estimation models may help this purpose. In this work, the development and validation of a new three-dimensional (3D) analytical model to assess the photon peripheral dose during radiotherapy is presented. It needs only two treatment-specific input parameter values, plus information about the linac-specific leakage, when available. It is easy to use and generates 3D whole-body dose distributions and, particularly, the dose to out-of-field organs (as dose–volume histograms) outside the 5% isodose for any isocentric treatment using coplanar beams [including intensity modulated radiotherapy and volumetric modulated arc therapy (VMAT)]. The model was configured with the corresponding Monte Carlo simulation of the peripheral absorbed dose for a 6 MV abdomen treatment on the International Comission on Radiological Protection (ICRP) 110 computational phantom. It was then validated with experimental measurements using thermoluminescent dosimeters in the male ATOM anthropomorphic phantom irradiated with a VMAT treatment for prostate cancer. Additionally, its performance was challenged by applying it to a lung radiotherapy treatment very different from the one used for training. The model agreed well with measurements and simulated dose values. A graphical user interface was developed as a first step to making this work more approachable to a daily clinical application.
dc.description.funderFONDECYT
dc.description.funderANID
dc.fechaingreso.objetodigital2023-01-16
dc.fuente.origenSCOPUS
dc.identifier.doi10.3389/fonc.2022.872752
dc.identifier.issn2234-943X
dc.identifier.scopusidSCOPUS_ID:85140373878
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fonc.2022.872752/full
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66350
dc.information.autorucInstituto de física ; Sánchez Nieto, Beatriz ; 0000-0003-0713-3108 ; 192291
dc.information.autorucInstituto de física ; López Martínez, Ignacio N. ; S/I ; 1025627
dc.information.autorucInstituto de física ; Espinoza Bornscheuer, Ignacio Guillermo ; S/I ; 131177
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaFrontiers in Oncology
dc.rightsacceso abierto
dc.subjectAnalytical model
dc.subjectMonte Carlo
dc.subjectPeriphocal
dc.subjectPhoton out-of-field dose
dc.subjectPhoton peripheral dose
dc.subjectRadiotherapy
dc.subjectSecondary cancer
dc.subjectStochastic radiation risk
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA simple analytical model for a fast 3D assessment of peripheral photon dose during coplanar isocentric photon radiotherapy
dc.typeartículo
dc.volumen12
sipa.codpersvinculados192291
sipa.codpersvinculados1025627
sipa.codpersvinculados131177
sipa.indexSCOPUS
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