Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases

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dc.article.number1467
dc.catalogadorpva
dc.contributor.authorFunes, Samanta Celeste
dc.contributor.authorRios Raggio, Mariana
dc.contributor.authorFernández Fierro, Ayleen Lorena
dc.contributor.authorCovián, Camila
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorRiedel Soria, Claudia
dc.contributor.authorMackern Oberti, Juan Pablo
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.date.accessioned2024-01-23T20:10:27Z
dc.date.available2024-01-23T20:10:27Z
dc.date.issued2020
dc.description.abstractHeme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.
dc.description.funderCorporación de Fomento de la Producción
dc.description.funderDepartment of Microbiology and Immunology of the University of Iowa
dc.fechaingreso.objetodigital2024-01-23
dc.fuente.origenScopus
dc.identifier.doi10.3389/fimmu.2020.01467
dc.identifier.eissn16643224
dc.identifier.issn1664-3224
dc.identifier.pubmedidMEDLINE:32849503
dc.identifier.scopusidSCOPUS_ID:85089097347
dc.identifier.urihttps://doi.org/10.3389/fimmu.2020.01467
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80926
dc.identifier.wosidWOS:000560065100001
dc.information.autorucFacultad de Ciencias Biológicas; Funes, Samanta Celeste; 0000-0002-1332-7569; 1062325
dc.information.autorucFacultad de Ciencias Biológicas; Rios Raggio, Mariana; S/I; 50388
dc.information.autorucFacultad de Ciencias Biológicas; Fernández Fierro, Ayleen Lorena; S/I; 1126909
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas; Riedel Soria, Claudia; S/I; 88772
dc.information.autorucFacultad de Ciencias Biológicas; Mackern Oberti, Juan Pablo; 0000-0001-9437-0579; 1009722
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final21
dc.pagina.inicio1
dc.publisherFrontiers Media S.A.
dc.revistaFrontiers in Immunologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHeme oxygenase 1es_ES
dc.subjectHO-1es_ES
dc.subjectAutoimmunityes_ES
dc.subjectNaturally derived compoundses_ES
dc.subjectInflammationes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNaturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseaseses_ES
dc.typeartículo de revisión
dc.volumen11
sipa.codpersvinculados1062325
sipa.codpersvinculados50388
sipa.codpersvinculados1126909
sipa.codpersvinculados113541
sipa.codpersvinculados88772
sipa.codpersvinculados1009722
sipa.codpersvinculados90610
sipa.trazabilidadScopus;12-10-2021
sipa.trazabilidadORCID;2024-01-15
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