Guillain-Barre Syndrome and Hydrocephalus in an infant with Wiskott-Aldrich Syndrome

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dc.contributor.authorAvila Smirnow, Daniela
dc.contributor.authorCordova Aguilera, Marcela
dc.contributor.authorCantillano Malone, Christian
dc.contributor.authorArriaza Ortiz, Manuel
dc.contributor.authorWegner Araya, Adriana
dc.date.accessioned2024-01-10T12:05:44Z
dc.date.available2024-01-10T12:05:44Z
dc.date.issued2020
dc.description.abstractGuillain-Barre Syndrome (GBS) is rarely diagnosed in the first year of life. The association of GBS with Wiskott-Aldrich syndrome (WAS) is even less frequent and has been previously reported in only two children to our knowledge. Hydrocephalus is a known but rare complication of GBS. Objective: To describe the case of an infant in which GBS, WAS and hydrocephalus appear clinically associated. Clinical Case: A nine-months-old male infant with a history of WAS was admitted to our ICU with acute hypotonia and poor general condition. He developed flaccid paralysis, absent deep tendon reflexes, and respiratory failure. A lumbar puncture showed albuminocytologic dissociation. GBS was suspected and an electromyography was performed, showing a demyelinating polyneuropathy. He was successfully treated with intravenous immunoglobulins. During hospitalization, he presented intermittent bradycardia, so a brain CT scan was performed, showing acute hydrocephalus which was managed through an external ventricular drain achieving favorable response. In the long term, the patient underwent bone marrow transplant and had to be reoperated due to valve-related complications. However, his psychomotor development is normal, with no obvious neurological sequelae. Conclusion: We present the third case of GBS in a patient with WAS, which is the first infant younger than one year. Additionally, he presented acute hydrocephalus as a complication of GBS. We suggest considering these three comorbidities since their early diagnosis and prompt management allow better neurological recovery and avoid potentially lethal complications.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.32641/rchped.v91i1.1208
dc.identifier.eissn0717-6228
dc.identifier.issn0370-4106
dc.identifier.pubmedidMEDLINE:32730420
dc.identifier.urihttps://doi.org/10.32641/rchped.v91i1.1208
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76061
dc.identifier.wosidWOS:000529831500014
dc.information.autorucMedicina;Arriaza Ortiz Manuel Antonio;S/I;161520
dc.information.autorucMedicina;Avila Smirnow Daniela;S/I;9292
dc.information.autorucMedicina;Cantillano Malone Christian Ju;S/I;175137
dc.information.autorucMedicina;Cordova Aguilera Marcela Paz;S/I;7442
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final110
dc.pagina.inicio105
dc.publisherSOC CHILENA PEDIATRIA
dc.revistaREVISTA CHILENA DE PEDIATRIA-CHILE
dc.rightsacceso abierto
dc.subjectElectromyography
dc.subjectGuillain-Barre
dc.subjectSyndrome
dc.subjectWiskott-Aldrich
dc.subjectSyndrome
dc.subjectImmunoglobulins
dc.subjectBone Marrow
dc.subjectTransplantation
dc.subjectPATIENT
dc.subjectFEATURES
dc.subjectBOY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGuillain-Barre Syndrome and Hydrocephalus in an infant with Wiskott-Aldrich Syndrome
dc.typeartículo
dc.volumen91
sipa.codpersvinculados161520
sipa.codpersvinculados9292
sipa.codpersvinculados175137
sipa.codpersvinculados7442
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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