Vitamin D status and supplementation in Antarctica: a systematic review and meta- analysis

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dc.catalogadorjca
dc.contributor.authorCabalin, Carolina
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorPerez Mateluna, Guillermo
dc.contributor.authorEcheverria, Denise
dc.contributor.authorCamargo Jr, Carlos A.
dc.contributor.authorBorzutzky Schachter, Arturo
dc.date.accessioned2024-01-10T14:23:47Z
dc.date.available2024-01-10T14:23:47Z
dc.date.issued2021
dc.description.abstractLiving at high latitudes is associated with vitamin D (VD) deficiency. An ideal setting to study this is the Antarctic continent, which has temporary inhabitants, but the magnitude of the effect of living in Antarctica and the effects of VD supplementation on this population remain unclear. We performed a systematic review and meta-analysis to assess the effect of temporary residence in Antarctica and impact of VD supplementation on VD status of this population. Random-effects meta-analyses were performed to assess serum 25-hydroxyvitamin D (25(OH)D) concentration changes after Antarctic residence (13 studies, 294 subjects) and after VD supplementation (5 studies, 213 subjects). Serum 25(OH)D mean difference after temporary residence in Antarctica was -15.0 nmol/L (95%CI: -25.9, -4.2; I-2=92%). Subgroup meta-analyses of studies evaluating Antarctic summer and winter stays showed 25(OH)D only decreases when overwintering (winter 25(OH)D change -17.0 nmol/L [95%CI: -24.1, -9.8; I-2=83%] vs. summer 25(OH)D change 1.3 nmol/L [95%CI: -14.6, 17.1; I-2=86%]). The meta-analysis of VD supplementation studies in Antarctica showed a mean 25(OH)D increase after supplementation of 10.8 nmol/L (95%CI: 3.3, 18.3; I-2=88%). In conclusion, VD status significantly worsens after inhabiting Antarctica, particularly when over-wintering. VD supplementation can prevent worsening of VD status and should be considered in this population.
dc.description.funderInstituto Antartico Chileno
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1080/22423982.2021.1926133
dc.identifier.eissn2242-3982
dc.identifier.issn1239-9736
dc.identifier.pubmedidMEDLINE:33983101
dc.identifier.urihttps://doi.org/10.1080/22423982.2021.1926133
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80141
dc.identifier.wosidWOS:000649939700001
dc.information.autorucEscuela de Medicina; Borzutzky Schachter Arturo Jose; 0000-0002-7904-262X; 5897
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsregistro bibliográfico
dc.subjectVitamin D
dc.subjectVitamin D deficiency
dc.subject25-hydroxyvitamin D
dc.subjectAntarctica
dc.subjectmeta-analysis
dc.subjectSUNLIGHT DEPRIVATION
dc.subjectMETABOLISM
dc.subjectLATITUDE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVitamin D status and supplementation in Antarctica: a systematic review and meta- analysis
dc.typeartículo de revisión
dc.volumen80
sipa.codpersvinculados5897
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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