Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

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dc.contributor.authorContreras Saavedra, Osvaldo Isaías
dc.contributor.authorRossi, Fabio M.
dc.contributor.authorTheret, Marine
dc.date.accessioned2021-07-06T14:48:02Z
dc.date.available2021-07-06T14:48:02Z
dc.date.issued2021
dc.date.updated2021-07-04T00:03:20Z
dc.description.abstractAbstract Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism—all the functions needed for an individual’s health and well-being. The muscle connective tissue’s main components are the extracellular matrix and its resident stromal cells, which continuously reshape it in embryonic development, homeostasis, and regeneration. Fibro-adipogenic progenitors are enigmatic and transformative muscle-resident interstitial cells with mesenchymal stem/stromal cell properties. They act as cellular sentinels and physiological hubs for adult muscle homeostasis and regeneration by shaping the microenvironment by secreting a complex cocktail of extracellular matrix components, diffusible cytokines, ligands, and immune-modulatory factors. Fibro-adipogenic progenitors are the lineage precursors of specialized cells, including activated fibroblasts, adipocytes, and osteogenic cells after injury. Here, we discuss current research gaps, potential druggable developments, and outstanding questions about fibro-adipogenic progenitor origins, potency, and heterogeneity. Finally, we took advantage of recent advances in single-cell technologies combined with lineage tracing to unify the diversity of stromal fibro-adipogenic progenitors. Thus, this compelling review provides new cellular and molecular insights in comprehending the origins, definitions, markers, fate, and plasticity of murine and human fibro-adipogenic progenitors in muscle development, homeostasis, regeneration, and repair.
dc.format.extent25 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationSkeletal Muscle. 2021 Jul 01;11(1):16
dc.identifier.doi10.1186/s13395-021-00265-6
dc.identifier.urihttps://doi.org/10.1186/s13395-021-00265-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/60971
dc.information.autorucFacultad de Ciencias Biológicas ; Contreras Saavedra, Osvaldo Isaías ; 0000-0002-8722-9371 ; 179007
dc.issue.numeroNo. 16
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final25
dc.pagina.inicio1
dc.revistaSkeletal Musclees_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectMesenchymal stromal/stem celles_ES
dc.subjectFibro/adipogenic progenitores_ES
dc.subjectFibroblastes_ES
dc.subjectAdipocytees_ES
dc.subjectRegenerationes_ES
dc.subjectSingle-cell RNAseqes_ES
dc.subject.ddc573.7
dc.subject.deweyBiologíaes_ES
dc.titleOrigins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitionses_ES
dc.typeartículo
dc.volumenVol. 11
sipa.codpersvinculados179007
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