Low circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infection

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dc.catalogadorpau
dc.contributor.authorMazaki-Tovi, Shali
dc.contributor.authorRomero, Roberto
dc.contributor.authorVaisbuch, Edi
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorErez, Offer
dc.contributor.authorMittal, Pooja
dc.contributor.authorKwon Kim, Sun
dc.contributor.authorGotsch, Francesca
dc.contributor.authorLamont, Ronald
dc.contributor.authorOgge, Giovanna
dc.contributor.authorPacora, Percy
dc.contributor.authorGoncalves, Luis
dc.contributor.authorJai Kim, Chong
dc.contributor.authorGómez Mora, Ricardo Alberto
dc.contributor.authorEspinoza, Jimmy
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorKusanovic, Juan Pedro
dc.date.accessioned2023-07-10T20:37:47Z
dc.date.available2023-07-10T20:37:47Z
dc.date.issued2010
dc.description.abstractObjective: An emerging theme in modern biology is that adipose tissue can respond to metabolic stress, and to inflammatory stimuli, by regulating the secretion of a complex network of soluble mediators, termed adipokines. Adiponectin, the most prevalent circulating adipokine in human, has profound insulin-sensitizing and anti-inflammatory properties. Indeed, the notion that adiponectin plays an important role in the interactions between the metabolic and the immune systems has been strongly suggested. Thus, the aim of this study was to determine if pyelonephritis during pregnancy is associated with changes in maternal serum adiponectin concentrations. Study design: This cross-sectional study included women in the following groups: 1) normal pregnant women (ns200); and 2) pregnant women with pyelonephritis (ns50). Maternal plasma adiponectin concentrations were determined by ELISA. Non-parametric statistics were used for analyses. Results: 1) The median maternal plasma adiponectin concentration was lower in patients with pyelonephritis than in those with a normal pregnancy (P-0.001); 2) among pregnant women with a normal weight, patients with pyelonephritis had a lower median plasma adiponectin concentration than those with a normal pregnancy (P-0.001); 3) similarly, among overweight/obese patients, those with pyelonephritis had a lower median plasma adiponectin concentration than those with a normal pregnancy (P-0.001); and 4) the presence of pyelonephritis was independently associated with maternal plasma adiponectin concentrations after adjustment for maternal age, smoking, gestational age at sampling, and pregestational body mass index (BMI). Conclusion: 1) The findings that acute pyelonephritis in pregnancy is characterized by low maternal plasma concentrations of adiponectin in both lean and overweight/obese patients are novel and concur with the antiinflammatory properties of adiponectin; and 2) the results of this study support the notion that adiponectin may play a role in the intricate interface between inflammation and metabolism during pregnancy
dc.fechaingreso.objetodigital2023-07-10
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1515/JPM.2009.134
dc.identifier.issn1619-3997
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-76149094557&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74149
dc.information.autorucEscuela de Medicina ; Gómez Mora, Ricardo Alberto ; 0000-0001-9267-304X ; 80926
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final17
dc.pagina.inicio9
dc.revistaJournal of Perinatal Medicine
dc.rightsacceso abierto
dc.subjectAcute bacterial infection
dc.subjectAdipokines
dc.subjectAdiponectin
dc.subjectInfection
dc.subjectInflammation
dc.subjectPregnancy
dc.subjectPyelonephritis
dc.titleLow circulating maternal adiponectin in patients with pyelonephritis: adiponectin at the crossroads of pregnancy and infectiones_ES
dc.typeartículo
dc.volumen38
sipa.codpersvinculados80926
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