Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study

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dc.contributor.authorParra Soto, Solange
dc.contributor.authorFerreccio Readi, Catterina
dc.contributor.authorCowley, Emma S.
dc.contributor.authorRezende, Leandro F. M.
dc.contributor.authorMathers, John C.
dc.contributor.authorPell, Jill P.
dc.contributor.authorHo, Frederick K.
dc.contributor.authorCelis Morales, Carlos
dc.date.accessioned2021-01-19T11:34:49Z
dc.date.available2021-01-19T11:34:49Z
dc.date.issued2021
dc.date.updated2021-01-17T01:03:25Z
dc.description.abstractAbstract Background Adiposity is a strong risk factor for cancer incidence and mortality. However, most of the evidence available has focused on body mass index (BMI) as a marker of adiposity. There is limited evidence on relationships of cancer with other adiposity markers, and if these associations are linear or not. The aim of this study was to investigate the associations of six adiposity markers with incidence and mortality from 24 cancers by accounting for potential non-linear associations. Methods A total of 437,393 participants (53.8% women; mean age 56.3 years) from the UK Biobank prospective cohort study were included in this study. The median follow-up was 8.8 years (interquartile range 7.9 to 9.6) for mortality and 9.3 years (IQR 8.6 to 9.9) for cancer incidence. Adiposity-related exposures were BMI, body fat percentage, waist-hip ratio, waist-height ratio, and waist and hip circumference. Incidence and mortality of 24 cancers sites were the outcomes. Cox proportional hazard models were used with each of the exposure variables fitted separately on penalised cubic splines. Results During follow-up, 47,882 individuals developed cancer and 11,265 died due to cancer during the follow-up period. All adiposity markers had similar associations with overall cancer incidence. BMI was associated with a higher incidence of 10 cancers (stomach cardia (hazard ratio per 1 SD increment 1.35, (95% CI 1.23; 1.47)), gallbladder (1.33 (1.12; 1.58)), liver (1.27 (1.19; 1.36)), kidney (1.26 (1.20; 1.33)), pancreas (1.12 (1.06; 1.19)), bladder (1.09 (1.04; 1.14)), colorectal (1.10 (1.06; 1.13)), endometrial (1.73 (1.65; 1.82)), uterine (1.68 (1.60; 1.75)), and breast cancer (1.08 (1.05; 1.11))) and overall cancer (1.03 (1.02; 1.04)). All these associations were linear except for breast cancer in postmenopausal women. Similar results were observed when other markers of central and overall adiposity were used. For mortality, nine cancer sites were linearly associated with BMI and eight with waist circumference and body fat percentage. Conclusion Adiposity, regardless of the marker used, was associated with an increased risk in 10 cancer sites.
dc.format.extent14 páginas
dc.identifier.citationBMC Medicine. 2021 Jan 11;19(1):7
dc.identifier.doi10.1186/s12916-020-01848-8
dc.identifier.urihttps://doi.org/10.1186/s12916-020-01848-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/51207
dc.issue.numeroNo. 7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaBMC Medicinees_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectObesityes_ES
dc.subjectBody mass indexes_ES
dc.subjectWaist circumferencees_ES
dc.subjectBody fates_ES
dc.subjectCanceres_ES
dc.subjectUK Biobankes_ES
dc.subject.ddc616.398
dc.subject.deweyMedicina y saludes_ES
dc.titleAssociations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort studyes_ES
dc.typeartículo
dc.volumenVol. 19
sipa.codpersvinculados99684
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