CagA antibodies as a marker of virulence in Chilean patients with Helicobacter pylori infection

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dc.catalogadorpau
dc.contributor.authorHarris, Paul R.
dc.contributor.authorGodoy, A.
dc.contributor.authorArenillas, S.
dc.contributor.authorRiera, F.
dc.contributor.authorGarcia, D.
dc.contributor.authorEinisman, H.
dc.contributor.authorPena, A.
dc.contributor.authorRollan, T.
dc.contributor.authorDuarte, I.
dc.contributor.authorGuiraldes, E.
dc.contributor.authorPerez-Perez, G.
dc.date.accessioned2024-01-19T19:22:45Z
dc.date.available2024-01-19T19:22:45Z
dc.date.issued2003
dc.description.abstractBackground: The bacterial and host factors that influence the clinical outcomes of the Helicobacter pylori infection have not been fully identified. Cytotoxin-associated gene product (CagA), one of the virulence factors, has been associated with a more aggressive form of infection. The authors studied the relationship between CagA status and clinical outcome in Chilean children and adults with H. pylori infection. Methods: One hundred eighty consecutive patients undergoing upper gastrointestinal endoscopic analysis were enrolled after informed consent was obtained. Rapid urease test and histologic analysis were used to detect H. pylori infection. IgA and IgG antibodies to H. pylori whole cell antigen preparation and IgG antibodies to CagA were measured by enzyme-linked immunosorbent assay (ELISA). Results: H. pylori infection was detected in 42% of the patients by biopsy or urease test and in 38% and 20% of patients by IgG and IgA antibodies, respectively. The prevalence of H. Pylori either by the invasive or the serologic tests was directly related to patient age. Among patients with H. pylori, there was no significant association between age and prevalence of CagA. Nearly 70% of the patients with H. pylori and peptic ulcer disease had CagA-positive strains. In contrast, only 49% of the patients with chronic gastritis alone had CagA-positive strains (P < 0.05). Conclusions: In Chile, patients infected with H. pylori have a proportion of CagA-positive strains similar to that reported in developed countries. CagA prevalence was not significantly different in adults and children infected with H. pylori, suggesting that variations in clinical outcome may be related to host immune or environmental factors.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1097/00005176-200311000-00018
dc.identifier.issn0717-6228
dc.identifier.urihttps://doi.org/10.1097/00005176-200311000-00018
dc.identifier.urihttps://journals.lww.com/jpgn/fulltext/2003/11000/caga_antibodies_as_a_marker_of_virulence_in.18.aspx
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80847
dc.information.autorucEscuela de Medicina; Harris Diez, Paul Richard; 0000-0001-6226-0957; 80706
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaJournal of Pediatric Gastroenterology and Nutrition
dc.rightsacceso restringido
dc.subjectHelicobacter pylories_ES
dc.subjectCytotoxin-associated gene product (Ca-A)-childrenes_ES
dc.titleCagA antibodies as a marker of virulence in Chilean patients with Helicobacter pylori infectiones_ES
dc.typeartículo
dc.volumen37
sipa.codpersvinculados80706
sipa.trazabilidadORCID;2024-01-08
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