Actualización en el manejo clínico de la hipertensión hiporreninémica

Simple item page
dc.catalogadorvzp
dc.contributor.authorMacchiavello Theoduloz, Stefano Pietro Gian
dc.contributor.authorFardella Bello, Carlos Enrique
dc.contributor.authorBaudrand Biggs Rene Felipe
dc.date.accessioned2024-05-30T18:54:25Z
dc.date.available2024-05-30T18:54:25Z
dc.date.issued2019
dc.description.abstractThe renin-angiotensin-aldosterone system modulates volume, sodium and potassium homeostasis. In the setting of a high sodium diet, up to 30% of patients with hypertension have a low or suppressed renin and increased volume. This phenotype of low renin hypertension (LRH) is multifactorial and includes infrequent inherited genetic syndromes, milder phenotypes of classic diseases and environmental exposures. All these conditions have in common a higher cardiovascular risk mediated by the over activation of the mineralo corticoid receptor (MR), present not only in the kidney, but also in vasculature, myocardium and adipocytes. Consequently, the aim of LRH treatment goes beyond the control of blood pressure and requires antagonizing MR with specific pharmacologic agents, pursuing normalization of renin as a clinical objective. Due to the unusual evaluation of renin status by non-endocrinologists and lack of disease awareness, only a minority of hypertensive patients receive this pathophysiologically-driven treatment that should reduce cardiovascular outcomes.
dc.format.extent9 páginas
dc.fuente.origenConveris
dc.identifier.doi10.4067/S0034-98872019000400490
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:31344212
dc.identifier.urihttps://doi.org/10.4067/S0034-98872019000400490
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86109
dc.identifier.wosidWOS:000472530400013
dc.information.autorucEscuela de Medicina; Macchiavello Theoduloz Stefano Pietro Gian; S/I; 163717
dc.information.autorucEscuela de Medicina; Fardella Bello Carlos Enrique; 0000-0002-5500-4434; 66235
dc.information.autorucEscuela de Medicina; Baudrand Biggs Rene Felipe; 0000-0002-8655-4957; 1024
dc.issue.numero4
dc.language.isoen
dc.pagina.final498
dc.pagina.inicio490
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectAldosterone
dc.subjectHypertension
dc.subjectReceptors, Mineralocorticoids
dc.subjectRenin
dc.subjectSpironolactone
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleActualización en el manejo clínico de la hipertensión hiporreninémica
dc.title.alternativeUpdate in the clinical management of low renin hypertension
dc.typeartículo
dc.volumen147
sipa.codpersvinculados163717
sipa.codpersvinculados66235
sipa.codpersvinculados1024
sipa.trazabilidadConveris;20-07-2021
Files
Collections
Artículos de revistas