The N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues

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dc.contributor.authorRuiz, FH
dc.contributor.authorSilva, E
dc.contributor.authorInestrosa, NC
dc.date.accessioned2024-01-10T14:22:03Z
dc.date.available2024-01-10T14:22:03Z
dc.date.issued2000
dc.description.abstractPrion protein (PrP) has attracted considerable attention, mainly due to its involvement in transmissible spongiform encephalopathies. Toward its N-terminal region, PrP bears an octapeptide repeat which has been shown to bind copper. We found that a human synthetic peptide (PrP59-91), corresponding to the four repeats of Pro-His-Gly-Gly-Gly-Trp-Gly-Gln has the ability to reduce copper, A mutant peptide lacking tryptophan displayed only 24% of the wild-type copper-reducing activity. Experiments performed in a N-2 environment confirmed that O-2 is not involved in the reaction. Our results indicated that cell surface PrP, besides its ability to bind copper, bears the capacity to reduce copper in vitro. The potential physiological role of copper reduction by PrP is discussed, (C) 2000 Academic Press.
dc.fechaingreso.objetodigital2024-04-12
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1006/bbrc.2000.2270
dc.identifier.issn0006-291X
dc.identifier.pubmedidMEDLINE:10708581
dc.identifier.urihttps://doi.org/10.1006/bbrc.2000.2270
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79848
dc.identifier.wosidWOS:000086023600036
dc.information.autorucQuímica;Inestrosa N;S/I;99331
dc.information.autorucQuímica;Silva E;S/I;98771
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final495
dc.pagina.inicio491
dc.publisherACADEMIC PRESS INC
dc.revistaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
dc.rightsacceso restringido
dc.subjectALZHEIMERS-DISEASE
dc.subjectCONVERSION
dc.subjectBRAIN
dc.subjectFORM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe N-terminal tandem repeat region of human prion protein reduces copper: Role of tryptophan residues
dc.typeartículo
dc.volumen269
sipa.codpersvinculados99331
sipa.codpersvinculados98771
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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