Alternative language paradigms for functional magnetic resonance imaging as presurgical tools for inducing crossed cerebro-cerebellar language activations in brain tumor patients

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dc.catalogadorjwg
dc.contributor.authorThakkar Ishani, Rajendra
dc.contributor.authorArrano Carrasco, Leonardo Marcelo
dc.contributor.authorCortes Rivera, Barbara
dc.contributor.authorZunino Pesce, Romina Francesca
dc.contributor.authorMery Munoz, Francisco Javier
dc.contributor.authorRodríguez Fernandez, María
dc.contributor.authorSmits, Marion
dc.contributor.authorMendez Orellana, Carolina
dc.date.accessioned2023-09-26T13:24:58Z
dc.date.available2023-09-26T13:24:58Z
dc.date.issued2021
dc.description.abstractObjectives Crossed cerebro-cerebellar BOLD activations have recently come to light as additional diagnostic features for patients with brain tumors. The covert verb generation (VG) task is a widely used language paradigm to determine these language-related crossed activations. Here we demonstrate these crossed activations in two additional language paradigms, the semantic and phonological association tasks. We propose the merit of these tasks to language lateralization determination in the clinic as they are easy to monitor and suitable for patients with aphasia. Methods Patients with brain tumors localized at different cortical sites (n = 71) performed three language paradigms, namely the VG task as well as the semantic (SA) and phonological (PA) association tasks with button-press responses. Respective language activations in disparate cortical regions and the cerebellum were assigned laterality. Agreements in laterality between the two new tasks and the verb generation task were tested using Cohen's kappa. Results Both tasks significantly agreed in cortical and cerebellar lateralization with the verb generation task in patients. Additionally, a McNemar test confirmed the presence of crossed activations in the cortex and the cerebellum in the entire subject population. Conclusion We demonstrated that the semantic and phonological association tasks resulted in crossed cerebro-cerebellar language lateralization activations as those observed due to the covert verb generation task. This may suggest the possibility of these tasks being used conjointly with the traditional verb generation task, especially for subjects that may be unable to perform the latter.
dc.description.funderAgencia Nacional de Investigacion y Desarrollo (ANID Chile) grant FONDECYT
dc.description.funder2020 ANID doctoral scholarship
dc.fechaingreso.objetodigital2023-09-26
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00330-021-08137-9
dc.identifier.eissn1432-1084
dc.identifier.issn0938-7994
dc.identifier.pubmedidMEDLINE:34189601
dc.identifier.urihttps://doi.org/10.1007/s00330-021-08137-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74679
dc.identifier.wosidWOS:000668075700003
dc.information.autorucFacultad de Medicina; Mendez Orellana, Carolina Patricia; S/I; 1015155
dc.information.autorucEscuela de Medicina; Thakkar Ishani Rajendra; ; 1049787
dc.information.autorucEscuela de Medicina; Arrano Carrasco Leonardo Marcelo; ; 167342
dc.information.autorucEscuela de Medicina; Zunino Pesce Romina Francesca; ; 8932
dc.information.autorucEscuela de Medicina; Mery Munoz Francisco Javier; ; 3633
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Rodriguez Fernandez Maria; 0003 1966 2920; 1031920
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherSPRINGER
dc.revistaEUROPEAN RADIOLOGY
dc.rightsacceso restringido
dc.subjectLanguage
dc.subjectFunctional laterality
dc.subjectBrain neoplasms
dc.subjectCerebellum
dc.subjectMagnetic resonance imaging
dc.subjectRIGHT-HEMISPHERE
dc.subjectVERBAL FLUENCY
dc.subjectDOMINANCE
dc.subjectORGANIZATION
dc.subjectHANDEDNESS
dc.subjectLOCATION
dc.subjectTASK
dc.subjectMRI
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleAlternative language paradigms for functional magnetic resonance imaging as presurgical tools for inducing crossed cerebro-cerebellar language activations in brain tumor patients
dc.typeartículo
sipa.codpersvinculados1015155
sipa.codpersvinculados1049787
sipa.codpersvinculados167342
sipa.codpersvinculados8932
sipa.codpersvinculados3633
sipa.codpersvinculados1031920
sipa.indexWoS
sipa.trazabilidadWOS;18-03-2022
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