Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip

Riquelme Guzmán, Camilo; Contreras Saavedra, Osvaldo Isaías

Single-cell revolution unveils the mysteries of the regenerative mammalian digit tip

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Single-cell_revolution_unveils_the_mysteries.pdf(530.73 KB)

Date

2020

Authors

Riquelme Guzmán, Camilo

Contreras Saavedra, Osvaldo Isaías

Abstract

The digit tip is an exciting model for studying regeneration in mammals, but the precise mechanisms and the populations of cells involved in the formation and remodeling of the blastema remain unknown. In an exciting new work, Storer et al. take advantage of single-cell RNAseq combined with Pdgfra+ lineage-tracing to open the way into the enigmatic world of mammalian tissue regeneration.

Keywords

Regeneration, PDGFRA, Wound healing, MSCs, Epimorphic regeneration, Fibroblasts, Mesenchymal progenitors, Repair, Blastema

URI

https://doi.org/10.1016/j.ydbio.2020.02.002
https://repositorio.uc.cl/handle/11534/67216

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