The use of β2-adrenoreceptor agonists in viral bronchiolitis: scientific rationale beyond evidence-based guidelines

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dc.contributor.authorNino, Gustavo
dc.contributor.authorRodríguez-Martínez, Carlos E.
dc.contributor.authorCastro Rodríguez, José Antonio
dc.date.accessioned2022-01-28T12:11:26Z
dc.date.available2022-01-28T12:11:26Z
dc.date.issued2020
dc.description.abstractDespite scientific evidence proving that inhaled β2-adrenergic receptor (β2-AR) agonists can reverse bronchoconstriction in all ages, current guidelines advocate against the use of β2-AR bronchodilators in infants with viral bronchiolitis because clinical trials have not demonstrated an overall clinical benefit. However, there are many different types of viral bronchiolitis, with variations occurring at an individual and viral level. To discard a potentially helpful treatment from all children regardless of their clinical features may be unwarranted. Unfortunately, the clinical criteria to identify the infants that may benefit from bronchodilators from those who do not are not clear. Thus, we summarised the current understanding of the individual factors that may help clinicians determine the highest probability of response to β2-AR bronchodilators during viral bronchiolitis, based on the individual immunobiology, viral pathogen, host factors and clinical presentation.
dc.fechaingreso.objetodigital2024-04-22
dc.format.extent8 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1183/23120541.00135-2020
dc.identifier.eissn2312-0541
dc.identifier.urihttps://doi.org/10.1183/23120541.00135-2020
dc.identifier.urihttps://www.doi.org/10.1183/23120541.00135-2020
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/63251
dc.information.autorucEscuela de medicina ; Castro Rodríguez, José Antonio ; 0000-0002-0708-4281 ; 113247
dc.issue.numeroNo. 4
dc.language.isoen
dc.nota.accesoContenido completo
dc.provenancepolivero 2022-01-28 09:11:24
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherMedicina
dc.titleThe use of β2-adrenoreceptor agonists in viral bronchiolitis: scientific rationale beyond evidence-based guidelines
dc.typeartículo
dc.volumenVol. 6
sipa.codpersvinculados113247
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