Growth Perturbations in a Phenotype with Rapid Fetal Growth Preceding Preterm Labor and Term Birth

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dc.contributor.authorLampl, Michelle
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorErez, Offer
dc.contributor.authorGotsch, Francesca
dc.contributor.authorEspinoza, Jimmy
dc.contributor.authorGoncalves, Luis
dc.contributor.authorLee, Wesley
dc.contributor.authorGomez, Ricardo
dc.contributor.authorKae Nien, Jyh
dc.contributor.authorFrongillo, Edward A.
dc.contributor.authorRomero, Roberto
dc.date.accessioned2024-01-10T12:39:18Z
dc.date.available2024-01-10T12:39:18Z
dc.date.issued2009
dc.description.abstractThe variability in fetal growth rates and gestation duration in humans is not well understood. Of interest are women presenting with an episode of preterm labor and subsequently delivering a term neonate, who is small relative to peers of similar gestational age. To further understand these relationships, fetal growth patterns predating an episode of preterm labor were investigated. Retrospective analysis of fetal biometry assessed by serial ultrasound in a prospectively studied sample of pregnancies in Santiago, Chile, tested the hypothesis that fetal growth patterns among uncomplicated pregnancies (n = 3,706) and those with an episode of preterm labor followed by term delivery (n = 184) were identical across the time intervals 16-22 weeks, 22-28 weeks, and 28-34 weeks in a multilevel mixed-effects regression. The hypothesis was not supported. Fetal weight growth rate was faster from 16 weeks among pregnancies with an episode of preterm labor (P < 0.05), declined across midgestation (22-28 weeks, P < 0.05), and rebounded between 28 and 34 weeks (P = 0.06). This was associated with perturbations in abdominal circumference growth and proportionately larger biparietal diameter from 22 gestational weeks (P = 0.03), greater femur (P = 0.01), biparietal diameter (P = 0.001) and head circumference (P = 0.02) dimensions relative to abdominal circumference across midgestation (22-28 weeks), followed by proportionately smaller femur diaphyseal length (P = 0.02) and biparietal diameter (P = 0.03) subsequently. A distinctive rapid growth phenotype characterized fetal growth preceding an episode of preterm labor among this sample of term-delivered neonates. Perturbations in abdominal circumference growth and patterns of proportionality suggest an altered growth strategy pre-dating the preterm labor episode. Am. J. Hum. Biol. 21:782-792, 2009. (C) 2009 Wiley-Liss, Inc.
dc.description.funderIntramural Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ajhb.20880
dc.identifier.eissn1520-6300
dc.identifier.issn1042-0533
dc.identifier.pubmedidMEDLINE:19298010
dc.identifier.urihttps://doi.org/10.1002/ajhb.20880
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77172
dc.identifier.wosidWOS:000271589100010
dc.information.autorucMedicina;Gómez R;S/I;80926
dc.information.autorucMedicina;Nien J;S/I;2778
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final792
dc.pagina.inicio782
dc.publisherWILEY
dc.revistaAMERICAN JOURNAL OF HUMAN BIOLOGY
dc.rightsacceso restringido
dc.subjectFOR-GESTATIONAL-AGE
dc.subjectINTRAUTERINE GROWTH
dc.subjectIN-UTERO
dc.subjectIMPRINTED GENES
dc.subjectFATTY LIVER
dc.subjectWEIGHT
dc.subjectPREGNANCY
dc.subjectHORMONE
dc.subjectCONSEQUENCES
dc.subjectGLUCOSE
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleGrowth Perturbations in a Phenotype with Rapid Fetal Growth Preceding Preterm Labor and Term Birth
dc.typeartículo
dc.volumen21
sipa.codpersvinculados80926
sipa.codpersvinculados2778
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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