Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

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dc.contributor.authorCordova-Delgado, Miguel
dc.contributor.authorPizarro, Gonzalo
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorHerrera, Maria Elisa
dc.contributor.authorGarrido, Marcelo
dc.date.accessioned2025-01-20T23:52:07Z
dc.date.available2025-01-20T23:52:07Z
dc.date.issued2021
dc.description.abstractSmall bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingly, one of them had gene alterations that affected signaling pathways previously described for SBA. However, a second patient displayed previously unreported alterations in this particular tumor type. Based on these findings we discuss potential treatment options for patients affected by this rare, aggressive disease.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fonc.2021.593561
dc.identifier.issn2234-943X
dc.identifier.urihttps://doi.org/10.3389/fonc.2021.593561
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94888
dc.identifier.wosidWOS:000631855300001
dc.language.isoen
dc.revistaFrontiers in oncology
dc.rightsacceso restringido
dc.subjectcase report
dc.subjectsmall bowel adenocarcinoma
dc.subjectcomprehensive genomic profiling
dc.subjectprecision oncology
dc.subjecttherapeutic options
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCase Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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