An update on neuropsychiatric lupus with emphasis in cognitive dysfunction

Abstract
Patients with systemic lupus erythematosus (SLE) suffer from a number of neuropsychiatric (NP) symptoms throughout their disease affecting them both physically and psychologically We review herein the nomenclature and case definitions for neuropsychiatric lupus syndromes proposed by the American College of Rheumatology in 1999. We emphasize cognitive dysfunction and discuss etiological hypotheses, especially those related to the presence of antineuronal autoantibodies. (Rev Med Chile 2012; 140; 1333-1341).
Description
Keywords
Autoantibodies, Lupus erythematosus systemic, Neurobehavioral manifestations, GLUTAMATE-RECEPTOR ANTIBODIES, NERVOUS-SYSTEM INVOLVEMENT, P-PROTEIN ANTIBODIES, BLOOD-BRAIN-BARRIER, CEREBROSPINAL-FLUID, CLINICAL-SIGNIFICANCE, PSYCHIATRIC-SYMPTOMS, SLE PATIENTS, ERYTHEMATOSUS, IMPAIRMENT
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