Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosus

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dc.contributor.authorGutierrez, MA
dc.contributor.authorGarcia, ME
dc.contributor.authorRodriguez, JA
dc.contributor.authorRivero, S
dc.contributor.authorJacobelli, S
dc.date.accessioned2024-01-10T13:13:33Z
dc.date.available2024-01-10T13:13:33Z
dc.date.issued1998
dc.description.abstractThe objective was to study the response of cortisol and of prolactin (PRL) to specific stimuli in systemic lupus erythematosus (SLE). We measured the response of cortisol to insulin-induced hypoglycemia and of PRL to thyrotropin releasing hormone (TRH) in seven patients with active untreated SLE and in ten paired control subjects. All were women with regular menstrual cycles. With the exception of two patients, they had never received corticosteroids before the study.
dc.description.abstractThe basal serum levels of cortisol (12.5 +/- 2.4 mu g/dl) and PRL (10.7 +/- 1.0 ng/ml) in the SLE group were not significantly different from those of the control group (12.3 +/- 1.1 mu g/dl and 13.7 +/- 2.4 ng/ml, respectively). The cortisol response after hypoglycemia was significantly lower in SLE patients compared to the control group at 45 min (P = 0.01), at 60 min (P = 0.009), and at 90 min (P = 0.001). The integrated cortisol response to hypoglycemia expressed as area under the response curve (AUC) did not differ significantly in either group (1447 +/- 187 vs 1828 +/- 84, P = 0.06). Although the peak of PRL after TRH did not differ significantly in both soups (68.0 +/- 7.4 ng/ml in SLE vs 66.3 +/- 77 ng/ml in controls) and the AUC of PRL response after TRH was comparable in both groups (4672 +/- 537 vs 4128 +/- 541, P = 0.32), the interval-specific 'delta' response was significantly higher in SLE than the control group at 0-60 min (P = 0.02) and 0-90 min (P = 0.01) after TRH injection.
dc.description.abstractThese findings suggest that active SLE is associated with some degree of dysfunction of the hypothalamic-pituitary-glucocorticoid axis and PRL secretion.
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1191/096120398678920343
dc.identifier.issn0961-2033
dc.identifier.pubmedidMEDLINE:9736324
dc.identifier.urihttps://doi.org/10.1191/096120398678920343
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78316
dc.identifier.wosidWOS:000075573000007
dc.information.autorucMedicina;Rivero S;S/I;98898
dc.information.autorucMedicina;Rodríguez J;S/I;98660
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final408
dc.pagina.inicio404
dc.publisherSTOCKTON PRESS
dc.revistaLUPUS
dc.rightsacceso restringido
dc.subjectlupus
dc.subjectcortisol
dc.subjectprolactin
dc.subjecthypothalamic-pituitary axis
dc.subjectAUTOIMMUNE-DISEASE
dc.subjectLEWIS RATS
dc.subjectNEUROENDOCRINE
dc.subjectARTHRITIS
dc.subjectSUSCEPTIBILITY
dc.subjectCOMMUNICATION
dc.subjectLYMPHOCYTES
dc.subjectSLE
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleHypothalamic-pituitary-adrenal axis function and prolactin secretion in systemic lupus erythematosus
dc.typeartículo
dc.volumen7
sipa.codpersvinculados98898
sipa.codpersvinculados98660
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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