Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease

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dc.contributor.authorIturriaga Agüera, Rodrigo
dc.contributor.authorRío Troncoso, Rodrigo Andre del
dc.contributor.authorIdiaquez, Juan.
dc.contributor.authorSomers, Virend K.
dc.date.accessioned2019-10-17T13:25:59Z
dc.date.available2019-10-17T13:25:59Z
dc.date.issued2016
dc.date.updated2019-10-14T19:11:33Z
dc.description.abstractAbstract The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.Abstract The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
dc.fuente.origenBiomed Central
dc.identifier.citationBiological Research. 2016 Feb 26;49(1):13
dc.identifier.doi10.1186/s40659-016-0073-8
dc.identifier.urihttps://doi.org/10.1186/s40659-016-0073-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26624
dc.identifier.wosidWOS:000371203200001
dc.issue.numeroNo. 13
dc.language.isoen
dc.pagina.final9
dc.pagina.inicio1
dc.revistaBiological Researches_ES
dc.rightsacceso abierto
dc.rights.holderIturriaga et al.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherCuerpo carotídeoes_ES
dc.subject.otherCorazón - Enfermedadeses_ES
dc.subject.otherSistema nervioso simpáticoes_ES
dc.titleCarotid body chemoreceptors, sympathetic neural activation, and cardiometabolic diseasees_ES
dc.typeartículo
dc.volumenVol. 49
sipa.codpersvinculados59784
sipa.codpersvinculados126608
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