Novel molecular insights and public omics data in pulmonary hypertension

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dc.contributor.authorLopez-Crisosto C.
dc.contributor.authorArias-Carrasco R.
dc.contributor.authorMaracaja-Coutinho V.
dc.contributor.authorLavandero S.
dc.contributor.authorLopez-Crisosto C.
dc.contributor.authorSepulveda P.
dc.contributor.authorVerdejo H.E.
dc.contributor.authorCastro P.F.
dc.contributor.authorSepulveda P.
dc.contributor.authorVerdejo H.E.
dc.contributor.authorCastro P.F.
dc.contributor.authorGarrido-Olivares L.
dc.contributor.authorLavandero S.
dc.date.accessioned2024-01-10T14:23:33Z
dc.date.available2024-01-10T14:23:33Z
dc.date.issued2021
dc.description.abstract© 2021 Elsevier B.V.Pulmonary hypertension is a rare disease with high morbidity and mortality which mainly affects women of reproductive age. Despite recent advances in understanding the pathogenesis of pulmonary hypertension, the high heterogeneity in the presentation of the disease among different patients makes it difficult to make an accurate diagnosis and to apply this knowledge to effective treatments. Therefore, new studies are required to focus on translational and personalized medicine to overcome the lack of specificity and efficacy of current management. Here, we review the majority of public databases storing ‘omics’ data of pulmonary hypertension studies, from animal models to human patients. Moreover, we review some of the new molecular mechanisms involved in the pathogenesis of pulmonary hypertension, including non-coding RNAs and the application of ‘omics’ data to understand this pathology, hoping that these new approaches will provide insights to guide the way to personalized diagnosis and treatment.
dc.description.funderAgencia Nacional de Investigaci?n y Desarrollo
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderVMC
dc.description.funderNational Heart, Lung and Blood Institute
dc.description.funderFONDECYT
dc.description.funderFONDAP
dc.fechaingreso.objetodigital19-04-2024
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.bbadis.2021.166200
dc.identifier.eissn1879260X
dc.identifier.issn1879260X 09254439
dc.identifier.pubmedid34144090
dc.identifier.scopusidSCOPUS_ID:85109363878
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2021.166200
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80110
dc.information.autorucFacultad de Medicina; Verdejo Pinochet, Hugo Eduardo; S/I; 1001175
dc.issue.numero166200
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherElsevier B.V.
dc.revistaBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.rightsacceso restringido
dc.subjectBioinformatics
dc.subjectEndoplasmic reticulum stress
dc.subjectEnergy metabolism
dc.subjectmicroRNAs
dc.subjectMitochondrial dysfunction
dc.subjectPulmonary hypertension
dc.titleNovel molecular insights and public omics data in pulmonary hypertension
dc.typeartículo de revisión
dc.volumen1867
sipa.codpersvinculados1001175
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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