Risk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome

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dc.catalogadorgrr
dc.contributor.authorGonzalez-Madrid, Enrique
dc.contributor.authorRangel-Ramirez, Ma. Andreina
dc.contributor.authorMendoza-Leon, Maria Jose
dc.contributor.authorAlvarez-Mardones, Oscar
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorOpazo, Ma. Cecilia
dc.contributor.authorRiedel, Claudia A.
dc.date.accessioned2024-01-25T23:59:33Z
dc.date.available2024-01-25T23:59:33Z
dc.date.issued2022
dc.description.abstractMultiple sclerosis (MS) is an autoimmune disease characterized by a robust inflammatory response against myelin sheath antigens, which causes astrocyte and microglial activation and demyelination of the central nervous system (CNS). Multiple genetic predispositions and environmental factors are known to influence the immune response in autoimmune diseases, such as MS, and in the experimental autoimmune encephalomyelitis (EAE) model. Although the predisposition to suffer from MS seems to be a multifactorial process, a highly sensitive period is pregnancy due to factors that alter the development and differentiation of the CNS and the immune system, which increases the offspring's susceptibility to develop MS. In this regard, there is evidence that thyroid hormone deficiency during gestation, such as hypothyroidism or hypothyroxinemia, may increase susceptibility to autoimmune diseases such as MS. In this review, we discuss the relevance of the gestational period for the development of MS in adulthood.
dc.fechaingreso.objetodigital2024-01-25
dc.format.extent25 páginas
dc.fuente.origenORCID-ene24
dc.identifier.doi10.3390/ijms23137080
dc.identifier.eissn1422-0067
dc.identifier.pubmedid35806081
dc.identifier.urihttp://doi.org/10.3390/ijms23137080
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80961
dc.identifier.wosidWOS:000825645600001
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero13
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectThyroid hormones
dc.subjectGestational period
dc.subjectHypothyroxinemia
dc.subjectImmune response
dc.subjectRisk factors
dc.subjectMultiple sclerosis
dc.subjectExperimental autoimmune encephalomyelitis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk Factors from Pregnancy to Adulthood in Multiple Sclerosis Outcome
dc.typeartículo
dc.volumen23
sipa.codpersvinculados15616
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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