Kanamycin treatment in the pre-symptomatic stage of a Drosophila PD model prevents the onset of non-motor alterations

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dc.article.number109573
dc.catalogadorjca
dc.contributor.authorMolina Mateo, Daniela
dc.contributor.authorValderrama, Benjamín
dc.contributor.authorZárate, Raffaela
dc.contributor.authorHidalgo, S.
dc.contributor.authorTamayo Leiva, Javier
dc.contributor.authorSoto González, Antonia
dc.contributor.authorGuerra Ayala, Simón
dc.contributor.authorArriagada Vera, Vicente
dc.contributor.authorOliva, C.
dc.contributor.authorDiez, B.
dc.contributor.authorCampusano, Jorge M.
dc.date.accessioned2024-02-27T16:02:48Z
dc.date.available2024-02-27T16:02:48Z
dc.date.issued2023
dc.description.abstractParkinson's disease (PD) is a neurodegenerative disorder characterized by motor alterations, which is preceded by a prodromal stage where non-motor symptoms are observed. Over recent years, it has become evident that this disorder involves other organs that communicate with the brain like the gut. Importantly, the microbial community that lives in the gut plays a key role in this communication, the so-called microbiota-gut-brain axis. Alterations in this axis have been associated to several disorders including PD. Here we proposed that the gut microbiota is different in the presymptomatic stage of a Drosophila model for PD, the Pink1B9 mutant fly, as compared to that observed in control animals. Our results show this is the case: there is basal dysbiosis in mutant animals evidenced by substantial difference in the composition of midgut microbiota in 8–9 days old Pink1B9 mutant flies as compared with control animals. Further, we fed young adult control and mutant flies kanamycin and analyzed motor and non-motor behavioral parameters in these animals. Data show that kanamycin treatment induces the recovery of some of the non-motor parameters altered in the pre-motor stage of the PD fly model, while there is no substantial change in locomotor parameters recorded at this stage. On the other hand, our results show that feeding young animals the antibiotic, results in a long-lasting improvement of locomotion in control flies. Our data support that manipulations of gut microbiota in young animals could have beneficial effects on PD progression and age-dependent motor impairments.
dc.fechaingreso.objetodigital2024-09-11
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.neuropharm.2023.109573
dc.identifier.issn0028-3908
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2023.109573
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81346
dc.information.autorucEscuela de Medicina;Molina Mateo, Daniela;S/I;205481
dc.information.autorucFacultad de Ciencias Biológicas;Valderrama, Benjamín;S/I;247378
dc.information.autorucFacultad de Ciencias Biológicas;Zárate Canales, Rafaella Victoria;0000-0001-7250-9007;1031192
dc.information.autorucFacultad de Ciencias Biológicas;Tamayo Leiva, Javier;S/I;1031203
dc.information.autorucFacultad de Ciencias Biológicas;Soto Gonzalez Antonia;S/I;1047200
dc.information.autorucFacultad de Ciencias Biológicas;Guerra Ayala, Simón;S/I;1066788
dc.information.autorucFacultad de Ciencias Biológicas;Arriagada Vera, Vicente;S/I;1066800
dc.information.autorucFacultad de Ciencias Biológicas;Campusano Astorga, Jorge;0000-0001-5254-8340;3965
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final12
dc.pagina.inicio1
dc.revistaNeuropharmacology
dc.rightsacceso restringido
dc.subjectParkinson's disease
dc.subjectDrosophila
dc.subjectPresymptomatic stage
dc.subjectMicrobiota
dc.subjectPink1
dc.subjectAging
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleKanamycin treatment in the pre-symptomatic stage of a Drosophila PD model prevents the onset of non-motor alterations
dc.typeartículo
dc.volumen236
sipa.codpersvinculados205481
sipa.codpersvinculados247378
sipa.codpersvinculados1031192
sipa.codpersvinculados1031203
sipa.codpersvinculados1047200
sipa.codpersvinculados1066788
sipa.codpersvinculados1066800
sipa.codpersvinculados3965
sipa.trazabilidadORCID;2024-01-15
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