The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model

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dc.contributor.authorUrrutia, Julio
dc.contributor.authorMardones, Rodrigo
dc.contributor.authorQuezada, Felipe
dc.date.accessioned2024-01-10T14:21:57Z
dc.date.available2024-01-10T14:21:57Z
dc.date.issued2007
dc.description.abstractObject. Several reports have shown that nonsteroidal antiinflammatory drugs (NSAIDs) have an inhibitory effect in osteogenesis and reduce heterotopic ossification in humans. A deleterious effect of NSAIDs in posterolateral intertransverse process fusion has also been suggested. The authors used a validated rabbit model to try to determine the influence of the NSAID ketoprophen on the fusion rate in lumbar spinal arthrodesis.
dc.description.abstractMethods. Thirty New Zealand male rabbits underwent posterolateral (intertransverse process) bilateral spinal fusions at a single level, using autologous bone graft obtained from both iliac crests. The animals were randomized after the operation, so that 15 rabbits received ketoprophen as a postoperative analgesic and the other 15 received the postoperative analgesic tramadol. The animals were killed 8 weeks after surgery, and fusion status was determined by inspection, palpation, anteroposterior radiographs, and histological analysis.
dc.description.abstractResults. A solid fusion was obtained in eight rabbits (53%), and pseudarthrosis in seven rabbits (47%) in each group.
dc.description.abstractConclusions. These findings suggest that the use of ketoprophen after intertransverse spinal fusion at a single level does not decrease the fusion rate, compared with tramadol.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3171/SPI-07/12/631
dc.identifier.eissn1547-5646
dc.identifier.issn1547-5654
dc.identifier.pubmedidMEDLINE:18074688
dc.identifier.urihttps://doi.org/10.3171/SPI-07/12/631
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79825
dc.identifier.wosidWOS:000251519900008
dc.information.autorucMedicina;Urrutia J;S/I;69910
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final636
dc.pagina.inicio631
dc.publisherAMER ASSOC NEUROLOGICAL SURGEONS
dc.revistaJOURNAL OF NEUROSURGERY-SPINE
dc.rightsacceso restringido
dc.subjectarthrodesis
dc.subjectketoprophen
dc.subjectnonsteroidal antiinflarnmatory drug
dc.subjectrabbit model
dc.subjectspine fusion
dc.subjecttramadol
dc.subjectTOTAL HIP-ARTHROPLASTY
dc.subjectHETEROTOPIC BONE-FORMATION
dc.subjectNONSTEROIDAL ANTIINFLAMMATORY DRUGS
dc.subjectOSTEOINDUCTIVE GROWTH-FACTOR
dc.subjectECTOPIC OSSIFICATION
dc.subjectMORPHOGENETIC PROTEIN-2
dc.subjectINDOMETHACIN
dc.subjectRAT
dc.subjectPREVENTION
dc.subjectARTHRODESIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe effect of ketoprophen on lumbar spinal fusion healing in a rabbit model
dc.typeartículo
dc.volumen7
sipa.codpersvinculados69910
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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