Serological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chile

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dc.contributor.authorCastro, Felipe A.
dc.contributor.authorDominguez, Angélica
dc.contributor.authorPuschel Illanes, Klaus
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorSnijders, Peter J.
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorPawlita, Michael
dc.contributor.authorFerreccio Readi, Catterina
dc.contributor.authorCastro, Felipe A.
dc.contributor.authorDominguez, Angélica
dc.contributor.authorPuschel Illanes, Klaus
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorSnijders, Peter J.
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorPawlita, Michael
dc.contributor.authorFerreccio Readi, Catterina
dc.date.accessioned2019-10-17T18:19:05Z
dc.date.available2019-10-17T18:19:05Z
dc.date.issued2014
dc.date.updated2019-10-14T18:29:03Z
dc.description.abstractAbstract Background Human papillomavirus (HPV) serology is a main factor for designing vaccination programs and surveillance strategies; nevertheless, there are few reports of HPV seroprevalence in the general population, especially in Latin America. This study aimed to describe high-risk HPV serological prevalence, persistence, and association with concurrent cervical infection, in Chilean women. Methods 1021 women from the general population, aged 15–85 years, were studied in 2001 of whom 600 were reexamined in 2006. The assessments at both time points included cervical HPV DNA testing, HPV antibody testing, cervical cytology and a sociodemographic/behavioral questionnaire. HPV DNA and antibodies against L1 protein of types 16, 18, 31, 33, 35, 45, 52, and 58 were assessed by reverse line blot and multiplex serology, respectively. Results Seropositivity was high at both baseline (43.2%) and follow-up (50.2%) and increased with age (p < 0.001); corresponding DNA prevalences were 6.7% and 8.7%. DNA and seroprevalence were associated at baseline (p = 0.01 for any HPV). Early age at first sexual intercourse and having had two or more sexual partners were independently associated with seropositivity. Most (82.0%) initially seropositive women remained seropositive at follow-up; 21.6% of initially seronegative women seroconverted, reaching 17.5% among women older than 60 years of age. ASCUS or worse cytology was correlated with HPV DNA positivity but not with HPV seropositivity. Conclusion HPV seroprevalence studies are a useful tool for learning about the dynamics of HPV infection in a community. This study contributes to understanding the natural history of HPV infection and provides a baseline assessment before the incorporation of HPV vaccination into a national program.
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Infectious Diseases. 2014 Jul 03;14(1):361
dc.identifier.doi10.1186/1471-2334-14-361
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26810
dc.issue.numeroNo.361
dc.language.isoen
dc.pagina.final8
dc.pagina.inicio1
dc.revistaBMC Infectious Diseaseses_ES
dc.rightsacceso abierto
dc.rights.holderCastro et al.; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherVacunas contra el Papillomavirus Humanoes_ES
dc.subject.otherSerologíaes_ES
dc.subject.otherVirus del Papiloma - Chilees_ES
dc.subject.otherVirus del Papiloma -Terapia - Chilees_ES
dc.titleSerological prevalence and persistence of high-risk human papillomavirus infection among women in Santiago, Chilees_ES
dc.typeartículo
dc.volumenVol.14
sipa.codpersvinculados131798
sipa.codpersvinculados83957
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