Free‐breathing 3D whole‐heart joint T1/T2 mapping and water/fat imaging at 0.55 T

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dc.catalogadorgrr
dc.contributor.authorSi, Dongyue
dc.contributor.authorCrabb, Michael G.
dc.contributor.authorKunze, Karl P.
dc.contributor.authorLittlewood, Simon J.
dc.contributor.authorPrieto Vasquez, Claudia Del Carmen
dc.contributor.authorBotnar, René M.
dc.date.accessioned2024-06-19T19:20:06Z
dc.date.available2024-06-19T19:20:06Z
dc.date.issued2024
dc.description.abstractTo develop and validate a highly efficient motion compensated free-breathingisotropic resolution 3D whole-heart joint T 1 /T2 mapping sequence with anatomicalwater/fat imaging at 0.55 T.Methods: The proposed sequence takes advantage of shorter T1 at 0.55 T to acquirethree interleaved water/fat volumes with inversion-recovery preparation, no prepara-tion, and T 2 preparation, respectively. Image navigators were used to facilitate nonrigidmotion-compensated image reconstruction. T1 and T2 maps were jointly calculated bya dictionary matching method. Validations were performed with simulation, phantom,and in vivo experiments on 10 healthy volunteers and 1 patient. The performance ofthe proposed sequence was compared with conventional 2D mapping sequences includ-ing modified Look-Locker inversion recovery and T2 -prepared balanced steady-SSFPsequence.Results: The proposed sequence has a good T1 and T2 encoding sensitivity in simula-tion, and excellent agreement with spin-echo reference T 1 and T2 values was observedin a standardized T1 /T2 phantom (R2 = 0.99). In vivo experiments provided good-qualityco-registered 3D whole-heart T1 and T2 maps with 2-mm isotropic resolution in ashort scan time of about 7 min. For healthy volunteers, left-ventricle T1 mean andSD measured by the proposed sequence were both comparable with those of modi-fied Look-Locker inversion recovery (640 ± 35 vs. 630 ± 25 ms [p = 0.44] and 49.9 ± 9.3vs. 54.4 ± 20.5 ms [p = 0.42]), whereas left-ventricle T2 mean and SD measured by theproposed sequence were both slightly lower than those of T2 -prepared balanced SSFP(53.8 ± 5.5 vs. 58.6 ± 3.3 ms [p < 0.01] and 5.2 ± 0.9 vs. 6.1 ± 0.8 ms [p = 0.03]). MyocardialT 1 and T2 in the patient measured by the proposed sequence were in good agreementwith conventional 2D sequences and late gadolinium enhancement.Conclusion: The proposed sequence simultaneously acquires 3D whole-heart T1 and T2mapping with anatomical water/fat imaging at 0.55 T in a fast and efficient 7-min scan.Further investigation in patients with cardiovascular disease is now warranted
dc.fechaingreso.objetodigital2024-08-27
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1002/mrm.30139
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.pubmedid38872384
dc.identifier.urihttps://doi.org/10.1002/mrm.30139
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86808
dc.information.autorucEscuela de Ingeniería; Botnar , Rene Michael; 0000-0003-2811-2509; 1015313
dc.information.autorucEscuela de Ingeniería; Prieto Vasquez, Claudia Del Carmen; 0000-0003-4602-2523; 14195
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaMagnetic Resonance in Medicine
dc.rightsacceso abierto
dc.rights.license CC BY 4.0 DEED Atribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectCardiac MRI
dc.subjectFree breathing
dc.subjectLow field
dc.subjectMyocardial T1 mapping
dc.subjectMyocardial T2 mapping
dc.subjectThree dimensional
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFree‐breathing 3D whole‐heart joint T1/T2 mapping and water/fat imaging at 0.55 T
dc.typeartículo
sipa.codpersvinculados1015313
sipa.codpersvinculados14195
sipa.trazabilidadORCID;2024-06-17
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