Effectiveness of Different Kidney Exchange Mechanisms to Improve Living Donor Transplantation in Chile

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dc.contributor.authorDominguez, J.
dc.contributor.authorHarrison, R.
dc.contributor.authorContreras, D.
dc.date.accessioned2024-01-10T12:05:04Z
dc.date.available2024-01-10T12:05:04Z
dc.date.issued2011
dc.description.abstractIntroduction. Chile has a low cadaveric organ donation rate; at the same time, living donor transplantation activity is also low. The purpose of this study was to analyze the impact on the number and quality of transplants using various mechanisms for kidney exchange from living donors to patients on Chile's waiting list.
dc.description.abstractMethods. A computerized model was developed to simulate five options for living kidney donation: (1) direct donation; (2) direct donation plus pairwise and three-way exchanges; (3) pairwise exchange; (4) three-way exchange; and (5) allocation of donors based on the top trading cycles (TTC) mechanism. We calculated the projected number of transplantations, adjusting for the risk of a positive crossmatch, as well as the average quality in terms of the human leukocyte antigen (HLA) match.
dc.description.abstractResults. If all patients on the waiting list have a willing direct donor, 47.7% of patients will receive a transplant. Allowing for incompatible pairs or pairs with a positive crossmatch an exchange of kidneys, can increase the number to 51.8%. This figure rises to 60% or 61% for pairwise or three-way exchanges, respectively. Although TTC ensures that 55% of the patients could be transplanted, the graft quality is better with an average HLA match of 3.5 versus 1.25.
dc.description.abstractConclusions. These results showed that kidney exchange mechanisms can increase the number of living donor transplantations by 4% and 13%.
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.transproceed.2011.06.001
dc.identifier.issn0041-1345
dc.identifier.pubmedidMEDLINE:21839256
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2011.06.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75942
dc.identifier.wosidWOS:000294102000045
dc.information.autorucInstituto de Economía;Contreras D ;S/I;162609
dc.information.autorucMedicina;Dominguez J ;S/I;73963
dc.information.autorucInstituto de Economía;Harrison R ;S/I;1003389
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final2287
dc.pagina.inicio2283
dc.publisherELSEVIER SCIENCE INC
dc.revistaTRANSPLANTATION PROCEEDINGS
dc.rightsacceso restringido
dc.subjectDONATION
dc.subjectALLOCATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffectiveness of Different Kidney Exchange Mechanisms to Improve Living Donor Transplantation in Chile
dc.typeartículo
dc.volumen43
sipa.codpersvinculados162609
sipa.codpersvinculados73963
sipa.codpersvinculados1003389
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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