Hypoadiponectinemia and its Association with Liver Fibrosis in Morbidly Obese Patients

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dc.catalogadorjwg
dc.contributor.authorNazal Ortiz, Leyla María
dc.contributor.authorRiquelme Pérez, Arnoldo Javier
dc.contributor.authorSolís López, Nancy De Las Mercedes
dc.contributor.authorPizarro Rojas, Margarita Alicia
dc.contributor.authorEscalona Pérez, Alex Gamaliel
dc.contributor.authorBurotto Pichun, Mauricio Emanuel
dc.contributor.authorMéndez, Juan Ignacio
dc.contributor.authorSaint-Jean, Catalina
dc.contributor.authorConcha Bustos, María José
dc.contributor.authorGiovanni, Stefano
dc.contributor.authorAwruch Diego Ariel
dc.contributor.authorMorales Soto, Arturo Javier
dc.contributor.authorBaudrand Biggs, Rene Felipe
dc.contributor.authorCarrasco Avino, Gonzalo
dc.contributor.authorDomínguez De Landa, María Angelica
dc.contributor.authorPadilla Pérez, Oslando
dc.contributor.authorEspinoza, Manuel
dc.contributor.authorMiquel, Juan Francisco
dc.contributor.authorNervi Oddone, Flavio
dc.contributor.authorArrese Jiménez, Marco Antonio
dc.date.accessioned2024-01-31T14:37:07Z
dc.date.available2024-01-31T14:37:07Z
dc.date.issued2010
dc.description.abstractReduced serum levels of adiponectin have been associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD). However, the relationship between serum adiponectin levels and hepatic histology in NAFLD is controversial. The aim of this study was to explore associations between plasma adiponectin concentrations and liver histology in morbidly obese patients.", "We conducted a case-control study including obese patients undergoing bariatric surgery and normal controls. Anthropometric, standard biochemical variables as well as plasma adiponectin and leptin levels were determined. Liver biopsy was performed in all patients at the time of surgery.", "Seventy morbidly obese patients (mean BMI, 40.6 +/- 5.6 kg/m(2)) met the inclusion criteria and were compared with 69 controls (mean BMI, 22.8 +/- 1.6 kg/m(2), p = 0.0001). Thirty patients (43%) had NAFLD and 20 (28%) of them fulfilled the histological criteria for steatohepatitis. Obesity was associated with increased leptin and decreased adiponectin levels. NAFLD patients exhibited decreased levels of serum adiponectin compared with matched controls [median (Q1-Q3), 3.9 (3.2-4.3) vs. 8.6 (6.5-9.2) mu g/mL, p < 0.0001]. In univariate analysis, age, gender, type 2 diabetes mellitus, BMI, HOMA-IR, aspartate aminotransferase (AST), alanine aminotransferase, serum glucose, and adiponectin levels were independently associated with hepatic fibrosis. In multivariate analysis, AST [OR = 1.082 (1.000-1.170)], age [OR = 1.119 (1.023-1.225)], and serum adiponectin levels [OR = 0.529 (0.299-0.936)] were significantly associated with the presence of liver fibrosis.", "NAFLD patients have lower plasma adiponectin concentrations than control subjects. Low adiponectin levels are associated with more severe liver histology. Serum adiponectin may be useful to estimate the severity of liver damage in obese patients with NAFLD.
dc.fuente.origenConveris
dc.identifier.converisid1
dc.identifier.doi10.1007/s11695-009-0051-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81159
dc.identifier.wosidWOS:000281986200010
dc.information.autorucEscuela de Medicina; Nazal Ortiz Leyla Maria; ; 19088
dc.information.autorucEscuela de Medicina; Riquelme Perez Arnoldo Javier; 0000-0002-8259-8960; 3538
dc.information.autorucEscuela de Medicina; Solis Lopez Nancy De Las Mercedes; ; 102379
dc.information.autorucEscuela de Medicina; Pizarro Rojas Margarita Alicia; 0000-0003-3063-3143; 102250
dc.information.autorucEscuela de Medicina; Escalona Perez Alex Gamaliel; ; 94025
dc.information.autorucEscuela de Medicina; Burotto Pichun Mauricio Emanuel; ; 146017
dc.information.autorucEscuela de Medicina; Concha Bustos Maria Jose; ; 174378
dc.information.autorucEscuela de Medicina; Arrese Jimenez Marco Antonio; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Nervi Oddone Flavio; 0000-0002-6642-7985; 99156
dc.information.autorucEscuela de Medicina; Carrasco Avino Gonzalo; ; 14818
dc.information.autorucEscuela de Medicina; Baudrand Biggs Rene Felipe; 0000-0002-8655-4957; 1024
dc.information.autorucEscuela de Medicina; Padilla Perez Oslando; ; 102063
dc.information.autorucEscuela de Medicina; Dominguez De Landa Maria Angelica; 0000-0001-7477-7574; 131798
dc.information.autorucEscuela de Medicina; Morales Soto Arturo Javier; ; 15243
dc.information.autorucS/I; Awruch Diego Ariel; S/I; 1007003
dc.issue.numero10
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1407
dc.pagina.inicio1400
dc.revistaObesity Surgery
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHypoadiponectinemia and its Association with Liver Fibrosis in Morbidly Obese Patients
dc.typeartículo
dc.volumen20
sipa.codpersvinculados19088
sipa.codpersvinculados3538
sipa.codpersvinculados102379
sipa.codpersvinculados102250
sipa.codpersvinculados94025
sipa.codpersvinculados146017
sipa.codpersvinculados174378
sipa.codpersvinculados76095
sipa.codpersvinculados1007003
sipa.codpersvinculados99156
sipa.codpersvinculados14818
sipa.codpersvinculados1024
sipa.codpersvinculados102063
sipa.codpersvinculados131798
sipa.codpersvinculados15243
sipa.trazabilidadORCID;2024-01-15
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