Physiological effects of high-flow nasal cannula during sustained high-intensity exercise in healthy volunteers: a randomised crossover trial

Simple item page
dc.catalogadorjlo
dc.contributor.authorMoya Gallardo, Eduardo Sebastián
dc.contributor.authorGarcía Valdés, Patricio Hernán
dc.contributor.authorMarambio Coloma, Consuelo Belén
dc.contributor.authorGutiérrez Escobar, Constanza Isidora
dc.contributor.authorHernández Vargas, Betsabeth Scarlet
dc.contributor.authorMuñoz Castro, Carolina Andrea
dc.contributor.authorRiquelme Sánchez, Santiago Martin
dc.contributor.authorMoo-Millán, Joel
dc.contributor.authorBasoalto Escobar, Roque Ignacio
dc.contributor.authorBruhn Cruz, Alejandro Rodrigo
dc.contributor.authorDíaz Patino, Orlando Alberto
dc.contributor.authorDamiani Rebolledo, Luis Felipe
dc.date.accessioned2024-10-29T13:13:54Z
dc.date.available2024-10-29T13:13:54Z
dc.date.issued2024
dc.description.abstractIntroductionHigh-flow nasal cannula (HFNC) has increased exercise capacity in patients with chronic respiratory diseases. However, it remains unknown whether HFNC impacts respiratory physiological variables during exercise. This study aimed to evaluate the effect of HFNC on respiratory physiological variables during sustained high-intensity exercise in healthy volunteers.MethodsWe performed a single-center, open-label, and randomised crossover trial to compare HFNC (60 L·min−1) and Sham-HFNC (2 L·min−1) interventions during a constant work-rate exercise (CWRET) through randomised order. The primary outcome was ΔPes, and the secondary outcomes were other variables of inspiratory effort, ventilation distribution, ventilatory variables, and clinical assessment. We evaluated volunteers at seven-time points (Baseline= T0; CWRET= T1-T2-T3 (minutes: 1′, 4′ and 6′); Cooldown-period= T4-T5-T6 (minutes: 1′; 6′;10′)) in both interventions.ResultsFourteen healthy volunteers (50% women; age: 22 [21–27] years) were enrolled. Mean differences in ΔPes decreased to favor the HFNC intervention compared to Sham-HFNC at T2 (−2.8 cmH2O; 95%CI −5.3 to −0.3), as well as the sPTPmin at T2 (−86.1 cmH2O×s·min−1;95%CI −146.2 to −26.1), and T3 (−79.9 cmH2O×s·min−1;95%CI −142.3 to −17.6). The standard deviation of the regional ventilation delay index was also lower with HFNC compared to Sham-HFNC (T1: −1.38; 95%CI −1.93 to −0.83; T2: −0.71; 95%CI −1.27 to −0.16). There was decreased dyspnea to favor the HFNC, but sPTP-per-breath, spatial distribution ventilation indexes, ventilatory variables, and clinical assessments were nonsignificant between interventions.ConclusionHFNC intervention reduces respiratory effort, dyspnea and improves temporal ventilation distribution in healthy volunteers during CWRET.
dc.fechaingreso.objetodigital2024-10-29
dc.format.extent59 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1183/23120541.00482-2024
dc.identifier.eissn2312-0541
dc.identifier.urihttps://doi.org/10.1183/23120541.00482-2024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88392
dc.information.autorucDepartamento de Ciencias de la Salud; Moya Gallardo, Eduardo Sebastián; 0000-0001-9356-9009; 234667
dc.information.autorucDepartamento de Ciencias de la Salud; García Valdés, Patricio Hernán; S/I; 1006675
dc.information.autorucDepartamento de Ciencias de la Salud; Marambio Coloma, Consuelo Belén; 0009-0002-3181-4704; 1089375
dc.information.autorucDepartamento de Ciencias de la Salud; Gutiérrez Escobar, Constanza Isidora; S/I; 1089362
dc.information.autorucDepartamento de Ciencias de la Salud; Hernández Vargas, Betsabeth Scarlet; S/I; 1089430
dc.information.autorucDepartamento de Ciencias de la Salud; Muñoz Castro, Carolina Andrea; S/I; 1089385
dc.information.autorucDepartamento de Ciencias de la Salud; Riquelme Sánchez, Santiago Martin; 0000-0002-1986-4955; 1028171
dc.information.autorucEscuela de Medicina; Basoalto Escobar, Roque Ignacio; 0000-0002-8908-7397; 1010703
dc.information.autorucEscuela de Medicina; Bruhn Cruz, Alejandro Rodrigo; 0000-0001-8034-1937; 741
dc.information.autorucEscuela de Medicina; Díaz Patino, Orlando Alberto; S/I; 78564
dc.information.autorucDepartamento de Ciencias de la Salud; Damiani Rebolledo, Luis Felipe; 0000-0002-8338-0488; 237645
dc.language.isoen
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC 4.0 Attribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.en
dc.subjectRespiratory physiology
dc.subjectElectrical impedance tomography
dc.subjectEsophageal manometry
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePhysiological effects of high-flow nasal cannula during sustained high-intensity exercise in healthy volunteers: a randomised crossover trial
dc.typeartículo
sipa.codpersvinculados234667
sipa.codpersvinculados1006675
sipa.codpersvinculados1089375
sipa.codpersvinculados1089362
sipa.codpersvinculados1089430
sipa.codpersvinculados1089385
sipa.codpersvinculados1028171
sipa.codpersvinculados1010703
sipa.codpersvinculados741
sipa.codpersvinculados78564
sipa.codpersvinculados237645
sipa.trazabilidadORCID;2024-10-28
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ERJ Open Res-2024-Moya-Gallardo-23120541.00482-2024.pdf
Size:
1.78 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas