The Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism

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dc.contributor.authorVera Otarola, Jorge
dc.contributor.authorSolis, Loretto
dc.contributor.authorSoto Rifo, Ricardo
dc.contributor.authorRicci, Emiliano P.
dc.contributor.authorPino, Karla
dc.contributor.authorTischler, Nicole D.
dc.contributor.authorOhlmann, Theophile
dc.contributor.authorDarlix, Jean Luc
dc.contributor.authorLopez Lastra, Marcelo
dc.date.accessioned2024-01-10T13:43:44Z
dc.date.available2024-01-10T13:43:44Z
dc.date.issued2012
dc.description.abstractThe small mRNA (SmRNA) of all Bunyaviridae encodes the nucleocapsid (N) protein. In 4 out of 5 genera in the Bunyaviridae, the smRNA encodes an additional nonstructural protein denominated NSs. In this study, we show that Andes hantavirus (ANDV) SmRNA encodes an NSs protein. Data show that the NSs protein is expressed in the context of an ANDV infection. Additionally, our results suggest that translation initiation from the NSs initiation codon is mediated by ribosomal subunits that have bypassed the upstream N protein initiation codon through a leaky scanning mechanism.
dc.description.funderProyecto Instituto Milenio
dc.description.funderFinanciado con Fondos Programa ICM
dc.description.funderPHS
dc.description.funderCONICYT
dc.description.funderMECESUP-USACH
dc.description.funderCONICYT, Chile
dc.description.funderFrench Embassy in Chile
dc.description.funderFondation pour la Recherche Medicale (FRM)
dc.description.funderFrench Ministry (MENRT)
dc.description.funderNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1128/JVI.06223-11
dc.identifier.eissn1098-5514
dc.identifier.issn0022-538X
dc.identifier.pubmedidMEDLINE:22156529
dc.identifier.urihttps://doi.org/10.1128/JVI.06223-11
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78740
dc.identifier.wosidWOS:000299862500026
dc.information.autorucMedicina;Lopez-Lastra M;S/I;84823
dc.information.autorucMedicina;Pino K ;S/I;1005654
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2187
dc.pagina.inicio2176
dc.publisherAMER SOC MICROBIOLOGY
dc.revistaJOURNAL OF VIROLOGY
dc.rightsacceso restringido
dc.subjectIMMUNODEFICIENCY-VIRUS TYPE-1
dc.subjectFEVER VIRUS
dc.subjectTRANSLATION INITIATION
dc.subjectEUKARYOTIC RIBOSOMES
dc.subjectINFECTED CELLS
dc.subjectHUMAN ISOLATE
dc.subjectS-RNA
dc.subjectINTERFERON
dc.subjectSEQUENCE
dc.subjectVALLEY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Andes Hantavirus NSs Protein Is Expressed from the Viral Small mRNA by a Leaky Scanning Mechanism
dc.typeartículo
dc.volumen86
sipa.codpersvinculados84823
sipa.codpersvinculados1005654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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