Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad

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dc.catalogadorgjm
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorRabagliati B., Ricardo
dc.contributor.authorBalcells Marty, María Elvira
dc.contributor.authorKarzulovic Busch, Lorena Karina
dc.contributor.authorPérez Cortés, Carlos
dc.date.accessioned2023-05-19T20:51:06Z
dc.date.available2023-05-19T20:51:06Z
dc.date.issued2008
dc.description.abstractBackground: Tuberculosis (TB) in Chile is reaching the elimination phase; however, in HIV positive individuals the incidence ofTB in still very high. Aim To describe the association between TB and HIV in different geographical regions in Chile, and to determine the association between TB and HIV/AIDS mortality. Patients and methods: A retrospective study that included individuals from the main HIV clinics from four regions with different TB prevalence in the general population (per 100,000): Arica (>30), Concepcion/Arauco (25-29), Valparaiso/San Antonio (20-24) and Metropolitana Sur-Oriente (SSMSO) (<20), attended between January 1998 and September 2004. Results: Nine hundred and twelve HIV positive individuals were included. Gobal prevalence ofTB was 6.2% [95% confidence intervals (Cl) 5.2-7.2%]. TB was more common in older subjects (p =0.039) and those with lower CD4 counts (p <0.001) and higher HIV viral load (p =0.033). In 66% of cases, the disease had a pulmonary localization. TB was the recorded cause of death in 7.4% of subjects. Only 29% of patients had a tuberculin skin test performed at the moment of HIV diagnosis. The prevalence of TB in HIV positive patients, followed the trend of TB prevalence in the general population: Concepcion/Arauco (11.9%), Valparaiso/San Antonio (7.1%) and SSMSO (3.9%). However HIV positive subjects from Arica showed an unexpectedly low TB prevalence (5.5%). Conclusions: TB in HIV/AIDS patients included in this study is over 300 times more prevalent than in the general population. TB prevalence in HIV positive subjects follows regional TB prevalence, excepting Arica. Effectiveness and feasibility of latent TB diagnostic strategies and treatment in HIV positive individuals should be reviewed.
dc.fechaingreso.objetodigital2023-07-14
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0034-98872008000500005
dc.identifier.issn0034-9887
dc.identifier.scieloidS0034-98872008000500005
dc.identifier.urihttps://doi.org/10.4067/S0034-98872008000500005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70418
dc.information.autorucEscuela de Medicina; Villarroel del Pino, Luis A.; 0000-0001-9603-937X; 77182
dc.information.autorucEscuela de Medicina; Rabagliati B., Ricardo; 0000-0002-0574-8312; 59169
dc.information.autorucEscuela de Medicina; Balcells Marty, María Elvira; 0000-0002-7223-9665; 7462
dc.information.autorucEscuela de Medicina; Karzulovic Busch, Lorena Karina; 0000-0003-3155-5706; 132805
dc.information.autorucEscuela de Medicina; Pérez Cortés, Carlos; S/I; 66650
dc.issue.numero5
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final586
dc.pagina.inicio578
dc.revistaRevista médica de Chile
dc.rightsacceso abierto
dc.subjectHIVes_ES
dc.subjectPrevalencees_ES
dc.subjectTuberculosises_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleTuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidades_ES
dc.title.alternativePrevalence of tuberculosis and its impact on mortality among HIV infected patients in Chilees_ES
dc.typeartículo
dc.volumen136
sipa.codpersvinculados77182
sipa.codpersvinculados59169
sipa.codpersvinculados7462
sipa.codpersvinculados132805
sipa.codpersvinculados66650
sipa.indexScielo
sipa.trazabilidadORCID;14-07-2023
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