Análisis crítico de un artículo: ¿Es confiable la medición de adenosin deaminasa (ADA) para el diagnóstico de derrame pleural tuberculoso?

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dc.catalogadorpau
dc.contributor.authorHerrera Riquelme, Cristian Alberto
dc.contributor.authorAravena León, Carlos Andrés
dc.date.accessioned2023-05-18T19:49:40Z
dc.date.available2023-05-18T19:49:40Z
dc.date.issued2009
dc.description.abstractBackground: Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of adenosine deaminase (ADA) in pleural fluid for the early diagnosis of tuberculous pleuresy. We conducted a metaanalysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy. Methods: After a systematic review of English language studies, sensitivity, specificity, and other measures of accuracy of ADA concentration in the diagnosis of pleural effusion were pooled using random effects models. Summary receiver operating characteristic curves were used to summarize overall test performance. Results: Sixty-three studies met our inclusion criteria. The summary estimates for ADA in the diagnosis of tuberculous pleurisy in the studies included were sensitivity 0.92 (95% confidence interval 0.90-0.93), specificity 0.90 (95% confidence interval 0.89-0.91), positive likelihood ratio 9.03 (95% confidence interval 7.19-11.35), negative likelihood ratio 0.10 (95% confidence interval 0.07-0.14), and diagnostic odds ratio 110.08 (95% confidence interval 69.96-173.20). Conclusions: ADA determination is a relative sensitive and specific test for the diagnosis of tuberculous pleurisy. Measurement of ADA in pleural effusion is thus likely to be a useful diagnostic tool for tuberculous plerisy. The results of ADA assays should be interpreted in parallel with clinical findings and the results of conventional tests
dc.format.extent3
dc.fuente.origenORCID
dc.identifier.doi10.4067/s0034-98872009000200019
dc.identifier.issn0034-9887
dc.identifier.urihttp://dx.doi.org/10.4067/s0034-98872009000200019
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67081
dc.information.autorucEscuela de Medicina; Herrera Riquelme, Cristian Alberto; 0000-0002-6219-7975; 142535
dc.information.autorucEscuela de Medicina; Aravena León, Carlos Andrés; S/I; 11079
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final311
dc.pagina.inicio308
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.titleAnálisis crítico de un artículo: ¿Es confiable la medición de adenosin deaminasa (ADA) para el diagnóstico de derrame pleural tuberculoso?
dc.title.alternativeCritically appraised article: Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A metaanalyses
dc.typeartículo
dc.volumen137
sipa.codpersvinculados142535
sipa.codpersvinculados11079
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