High temperature induces oxidative damage, immune modulation, and atrophy in the gills and skeletal muscle of the teleost fish black cusk-eel (Genypterus maculatus)

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dc.article.number105332
dc.catalogadorvdr
dc.contributor.authorBecerra, Sofía
dc.contributor.authorArriagada-Solimano M.
dc.contributor.authorEscobar Aguirre, Sebastián Gonzalo
dc.contributor.authorPalomino, Jaime
dc.contributor.authorAedo, Jorge
dc.contributor.authorEstrada, Juan Manuel
dc.contributor.authorBarra Valdebenito, Verónica
dc.contributor.authorZuloaga, Rodrigo
dc.contributor.authorValdés, Juan Antonio
dc.contributor.authorDettleff, Phillip
dc.date.accessioned2025-03-28T13:51:30Z
dc.date.available2025-03-28T13:51:30Z
dc.date.issued2025
dc.description.abstractThe high temperature associated with heat waves is a relevant abiotic factor that could impact the biology of teleost fish. The innate immune response, muscular growth, and oxidative stress status are relevant functions in fish tissues that could be affected by increased temperature. In this study, black cusk-eel (Genypterus maculatus) juveniles were subjected to increased temperature, to experimentally replicate heat waves registered from the South Pacific Ocean for five days. The results showed that thermal stress modulated the immune response in gills, with up-regulation of antibacterial peptides, pro-inflammatory cytokines, and Toll-like receptors genes, including hepcidin, gzma, tnfa, cxcl8, and tlr5, with no effect on complement system genes. In skeletal muscle, high temperature triggered atrophy-related gene expression, with up-regulation of foxo1, foxo3, fbxo32, murf1, and atg16l. Increased temperature also generated an up-regulation of transcripts encoding heat shock protein (hsp60 and hsp70) in gills and skeletal muscle, generating oxidative stress in both tissues, with increased expression of the antioxidant genes sod1 and gpx1 in gills and skeletal muscle, respectively, with oxidative damage observed at the DNA level (AP sites), protein (carbonyl content), and lipoperoxidation (HNE content) in both tissues. The present study shows that short-term increases in temperature like those observed in heat waves could affect the immune response in gills, induced atrophy in skeletal muscle, and generate oxidative stress in a teleost species important for Chilean aquaculture diversification, information relevant under the context of climate change scenario.
dc.fechaingreso.objetodigitalNo aplica
dc.format.extent9 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.dci.2025.105332
dc.identifier.eissn1879-0089
dc.identifier.scopusidSCOPUS_ID:85216587798
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103018
dc.information.autorucFacultad de Agronomía e Ingenieria Forestal; Escobar Aguirre, Sebastián Gonzalo; 0000-0001-8826-2096; 1092624
dc.information.autorucEscuela de Medicina Veterinaria; Barra Valdebenito, Verónica; S/I; 1376537
dc.information.autorucEscuela de Medicina Veterinaria; Dettleff, Phillip; 0000-0001-7619-046X; 1252622
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final9
dc.pagina.inicio1
dc.revistaDevelopmental and Comparative Immunology
dc.rightsacceso restingido
dc.subjectAtrophy
dc.subjectBlack cusk-eel
dc.subjectHeat waves
dc.subjectImmune response
dc.subjectOxidative stress
dc.subjectThermal stress
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods13 Climate action
dc.subject.odspa13 Acción por el clima
dc.titleHigh temperature induces oxidative damage, immune modulation, and atrophy in the gills and skeletal muscle of the teleost fish black cusk-eel (Genypterus maculatus)
dc.typeartículo
dc.volumen164
sipa.codpersvinculados1092624
sipa.codpersvinculados1376537
sipa.codpersvinculados1252622
sipa.trazabilidadSCOPUS;2025-02-23
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