Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry

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dc.catalogadorpva
dc.contributor.authorRajendran, Satheeshkumar
dc.contributor.authorSivalingam, Kalaiselvi
dc.contributor.authorKarnam Jayarampillai, Rajendra Prasad
dc.contributor.authorWang, Wen-Long
dc.contributor.authorSalas Sánchez, Cristián Osvaldo
dc.date.accessioned2025-03-25T20:11:17Z
dc.date.available2025-03-25T20:11:17Z
dc.date.issued2022
dc.description.abstractIn the current scenario of medicinal chemistry, quinoline plays a pivotal role in the design of new heterocyclic compounds with several pharmacological properties, so the search for new synthetic methodologies and their application in drug discovery has been widely studied. So far, many procedures have been performed for the preparation of quinoline scaffolds, among which Friedlander quinoline synthesis plays an important role in obtaining these heterocycles. The Friedlander reaction involves condensation between 2-aminobenzaldehydes and keto-compounds. The quinoline nucleus, once obtained through the Friedlander synthesis, has been extensively modified so that these derivatives can exhibit a large number of biological activities such as anticancer, antimalarial, antimicrobial, antifungal, antituberculosis, and antileishmanial properties. In this work, the focus is on the applicability of the Friedlander reaction in the synthesis of various types of bioactive heterocyclic quinoline compounds, which to date has not been reported in the context of medicinal chemistry. The main part of this review selectively focuses on research from 2010 to date and will present highlights of the Friedlander quinoline synthesis procedures and findings to address biological and pharmacological activities.
dc.description.funderFONDECYT
dc.format.extent44 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/cbdd.14044
dc.identifier.eissn1747-0285
dc.identifier.issn1747-0277
dc.identifier.scopusidSCOPUS_ID:85127573365
dc.identifier.urihttps://doi.org/10.1111/cbdd.14044
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102990
dc.identifier.wosidWOS:000779170700001
dc.information.autorucEscuela de Química; Salas Sánchez, Cristián Osvaldo; 0000-0001-7620-2459; 101425
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1085
dc.pagina.inicio1042
dc.publisherWILEY
dc.revistaChemical Biology and Drug Design
dc.rightsacceso restringido
dc.subjectBiological activities
dc.subjectFriedlander synthesis
dc.subjectHeterocycles
dc.subjectQuinoline derivatives
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFriedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry
dc.typeartículo de revisión
dc.volumen100
sipa.codpersvinculados101425
sipa.trazabilidadWOS;2022-07-08
sipa.trazabilidadORCID;2025-03-03
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