Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica

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dc.contributor.authorWinter J.L.
dc.contributor.authorCastro P.
dc.contributor.authorChalhub M.
dc.contributor.authorVerdejo H.
dc.contributor.authorGreig D.
dc.contributor.authorGabrielli L.
dc.contributor.authorHernández C.
dc.contributor.authorUribe S.
dc.contributor.authorMeneses L.
dc.contributor.authorChiong M.
dc.contributor.authorLavandero S.
dc.contributor.authorConcepción R.
dc.contributor.authorMellado R.
dc.date.accessioned2024-01-10T12:36:57Z
dc.date.available2024-01-10T12:36:57Z
dc.date.issued2010
dc.description.abstractBackground: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HF. Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 ± 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 ± 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/ Cr index, among patients with heart failure, when compared with healthy controls (1.46 ± 1.21 and 5.96 ± 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 ± 2.66 and 1.80 ± 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy.
dc.fechaingreso.objetodigital2024-05-30
dc.fuente.origenScopus
dc.identifier.doi10.4067/s0034-98872010001300001
dc.identifier.eissn07176163
dc.identifier.issn07176163 00349887
dc.identifier.pubmedid21526294
dc.identifier.scopusidSCOPUS_ID:79951608605
dc.identifier.urihttps://doi.org/10.4067/s0034-98872010001300001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76699
dc.information.autorucFacultad de Medicina; Verdejo Pinochet, Hugo Eduardo; S/I; 1001175
dc.language.isoes
dc.nota.accesoContenido parcial
dc.pagina.final1479
dc.pagina.inicio1475
dc.publisherSociedad Medica de Santiago
dc.revistaRevista Medica de Chile
dc.rightsacceso restringido
dc.subjectCreatine
dc.subjectHeart failure
dc.subjectMagnetic resonance spectroscopy
dc.titleDeterminaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
dc.title.alternativeMyocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
dc.typeartículo
dc.volumen138
sipa.codpersvinculados1001175
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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