Mentalization and epigenetic changes in psycotherapy of adolescents diagnosed with borderline personality disorder

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dc.contributor.advisorJiménez de la Jara, Juan Pablo
dc.contributor.authorQuevedo Labbé, Iván Yamil
dc.contributor.otherPontificia Universidad Católica de Chile. Escuela de Psicología
dc.date.accessioned2021-09-22T19:51:56Z
dc.date.available2021-09-22T19:51:56Z
dc.date.issued2021
dc.date.updated2021-09-21T19:46:44Z
dc.descriptionTesis (Doctor en Psicoterapía)--Pontificia Universidad Católica de Chile, 2021
dc.description.abstractGenetic and early environmental factors are interwoven in the etiopathogenesis of Borderline Personality Disorder (BPD). Epigenetic mechanisms, allow the molecular machinery to adapt to environmental conditions. There are gaps in the knowledge of how epigenetic mechanisms are involved in the effects of early affective environment, development of BPD and psychotherapy response. This work aims to explore changes in DNA methylation of FKBP5 gene, which encodes for a stress response protein, in relation to psychotherapy, on symptomatology and underlying psychological processes in a sample of 11 female adolescents diagnosed with BPD. For this purpose, measures of early trauma, borderline and depressive symptoms, psychotherapy outcome, mentalization and emotional regulation were studied longitudinally at baseline, 3 and 6 months. Percentage DNA methylation levels of FKBP5 gene intron 7 were measured at the same times. A significant reduction of borderline and depressive symptoms was found. No significant change was observed in emotional regulation and mentalization. A reduction in the average DNA methylation was observed over time. Additionally, it was observed that this decrease in methylation occurred only in those individuals who reported the presence of early trauma and responded to psychotherapy. The results support an effect of psychotherapy on epigenetic mechanisms associated with the stress response, specifically DNA methylation of FKBP5, which is concordant with previous studies in other phenotypes. The fact that the epigenetic change occurred only in the presence of early trauma is suggestive of a specific molecular mechanism of recovery. The results should be taken with caution given the small sample size. Further research is needed to include covariates that modify DNA methylation and incorporate endocrinological markers and therapeutic process variables. Psychotherapy focused on personality pathology could lead to changes in DNA methylation causing permanent reprogramming of phenotypic adaptation to the interpersonal environment.
dc.format.extent105 páginas
dc.fuente.origenAutoarchivo
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/62494
dc.information.autorucPontificia Universidad Católica de Chile ; Jiménez de la Jara, Juan Pablo ; 0000-0002-8679-6614 ; 1005766
dc.information.autorucPontificia Universidad Católica de Chile ; Iván Yamil Quevedo Labbé ; 0000-0001-6615-0915 ; 249945
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc616.8585200835
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherTrastorno de personalidad limítrofe - Terapiaes_ES
dc.subject.otherPsicoterapia - En adolescenciaes_ES
dc.titleMentalization and epigenetic changes in psycotherapy of adolescents diagnosed with borderline personality disorderes_ES
dc.typetesis doctoral
sipa.codpersvinculados1005766
sipa.codpersvinculados249945
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