Association of metabolic syndrome markers with abnormal alanine aminotransferase levels in healthy children

dc.contributor.authorArancibia, Gabriel
dc.contributor.authorGarcia, Hernan
dc.contributor.authorJaime, Francisca
dc.contributor.authorBancalari, Rodrigo
dc.contributor.authorHarris, Paul R.
dc.date.accessioned2024-01-10T13:46:10Z
dc.date.available2024-01-10T13:46:10Z
dc.date.issued2012
dc.description.abstractBackground: There is a high prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) among pediatric patients. The identification of clinical predictors of these conditions would allow a timely treatment. Aim: To evaluate the relationship between serum alanine aminotransferase levels and parameters of metabolic syndrome in asymptomatic school students without hepatic illness. Subjects and Methods: A randomized sample of 175 children aged between 9 and 14 years (54% females) was selected, from a database of 3010 students living in Santiago, Chile. Weight, height, abdominal circumference, systolic and diastolic blood pressure were measured. A fasting blood sample was obtained to measure glucose, total cholesterol, HDL, LDL-cholesterol, triglycerides, alanine aminotransferase (ALT) and insulin levels. Results: Forty percent of participants were obese, 17% had metabolic syndrome and 13.1% had abnormal ALT levels. Compared with children with normal ALT levels, the latter had significantly higher waist obesity, body mass index, systolic and diastolic blood pressure and triglycerides. However on multivariate analysis, only waist obesity was independently associated with abnormal ALT levels (adjusted odds ratio 3.93, 95% confidence intervals 1.44-10.78, p = 0.008). Conclusions: Only waist obesity was independently associated with abnormal ALT levels in this sample of children. (Rev Med Chile 2012; 140: 896-901).
dc.fechaingreso.objetodigital2024-05-28
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872012000700010
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:23282702
dc.identifier.urihttps://doi.org/10.4067/S0034-98872012000700010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79128
dc.identifier.wosidWOS:000308280100010
dc.information.autorucMedicina;Harris P;S/I;80706
dc.issue.numero7
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final901
dc.pagina.inicio896
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectAlanine transaminase
dc.subjectChild
dc.subjectFatty liver
dc.subjectMetabolic syndrome X
dc.subjectFATTY LIVER-DISEASE
dc.subjectOBESE CHILDREN
dc.subjectNONALCOHOLIC STEATOHEPATITIS
dc.subjectADOLESCENTS
dc.subjectPREVALENCE
dc.subjectSTEATOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAssociation of metabolic syndrome markers with abnormal alanine aminotransferase levels in healthy children
dc.typeartículo
dc.volumen140
sipa.codpersvinculados80706
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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