Clinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center trial

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dc.contributor.authorHajhosseiny, R.
dc.contributor.authorRashid, Imran
dc.contributor.authorBustin, Aurélien
dc.contributor.authorMunoz, Camila
dc.contributor.authorCruz, Gastao
dc.contributor.authorNazir, Muhummad Sohaib
dc.contributor.authorGrigoryan, Karine
dc.contributor.authorIsmail, Tevfk F.
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorBotnar, René Michael
dc.date.accessioned2021-05-25T15:35:23Z
dc.date.available2021-05-25T15:35:23Z
dc.date.issued2021
dc.date.updated2021-05-23T00:02:29Z
dc.description.abstractAbstract Background The widespread clinical application of coronary cardiovascular magnetic resonance (CMR) angiography (CMRA) for the assessment of coronary artery disease (CAD) remains limited due to low scan efficiency leading to prolonged and unpredictable acquisition times; low spatial-resolution; and residual respiratory motion artefacts resulting in limited image quality. To overcome these limitations, we have integrated highly undersampled acquisitions with image-based navigators and non-rigid motion correction to enable high resolution (sub-1 mm3) free-breathing, contrast-free 3D whole-heart coronary CMRA with 100% respiratory scan efficiency in a clinically feasible and predictable acquisition time. Objectives To evaluate the diagnostic performance of this coronary CMRA framework against coronary computed tomography angiography (CTA) in patients with suspected CAD. Methods Consecutive patients (n = 50) with suspected CAD were examined on a 1.5T CMR scanner. We compared the diagnostic accuracy of coronary CMRA against coronary CTA for detecting a ≥ 50% reduction in luminal diameter. Results The 50 recruited patients (55 ± 9 years, 33 male) completed coronary CMRA in 10.7 ± 1.4 min. Twelve (24%) had significant CAD on coronary CTA. Coronary CMRA obtained diagnostic image quality in 95% of all, 97% of proximal, 97% of middle and 90% of distal coronary segments. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were: per patient (100%, 74%, 55%, 100% and 80%), per vessel (81%, 88%, 46%, 97% and 88%) and per segment (76%, 95%, 44%, 99% and 94%) respectively. Conclusions The high diagnostic image quality and diagnostic performance of coronary CMRA compared against coronary CTA demonstrates the potential of coronary CMRA as a robust and safe non-invasive alternative for excluding significant disease in patients at low-intermediate risk of CAD.
dc.format.extent14 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2021 May 17;23(1):57
dc.identifier.doi10.1186/s12968-021-00758-9
dc.identifier.urihttps://doi.org/10.1186/s12968-021-00758-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/59535
dc.issue.numeroNo. 57
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.revistaJournal of Cardiovascular Magnetic Resonancees_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectCoronary artery diseasees_ES
dc.subjectCoronary magnetic resonance angiographyes_ES
dc.subjectCMRAes_ES
dc.subjectAtherosclerosises_ES
dc.subjectHigh resolutiones_ES
dc.subjectCoronary angiographyes_ES
dc.subject.ddc616.12
dc.subject.deweyMedicina y saludes_ES
dc.titleClinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center triales_ES
dc.typeartículo
dc.volumenVol. 23
sipa.codpersvinculados14195
sipa.codpersvinculados1015313
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