Efficient Lung Recruitment of Respiratory Syncytial Virus-Specific Th1 Cells Induced by Recombinant Bacillus Calmette-Guerin Promotes Virus Clearance and Protects from Infection

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dc.contributor.authorCautivo, Kelly M.
dc.contributor.authorBueno, Susan M.
dc.contributor.authorCortes, Claudia M.
dc.contributor.authorWozniak, Aniela
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-01-10T13:47:56Z
dc.date.available2024-01-10T13:47:56Z
dc.date.issued2010
dc.description.abstractInfection by the respiratory syncytial virus (RSV) can cause extensive inflammation and lung damage in susceptible hosts due to a Th2-biased immune response. Such a deleterious inflammatory response can be enhanced by immunization with formalin- or UV-inactivated RSV, as well as with vaccinia virus expressing the RSV-G protein. Recently, we have shown that vaccination with rBCG-expressing RSV Ags can prevent the disease in the mouse. To further understand the immunological mechanisms responsible for protection against RSV, we have characterized the T cell populations contributing to virus clearance in mice immunized with this BCG-based vaccine. We found that both CD4(+) and CD8(+) T cells were recruited significantly earlier to the lungs of infected mice that were previously vaccinated. Furthermore, we observed that simultaneous adoptive transfer of CD8(+) and CD4(+) RSV-specific T cells from vaccinated mice was required to confer protection against virus infection in naive recipients. In addition, CD4(+) T cells induced by vaccination released IFN-gamma after RSV challenge, indicating that protection is mediated by a Th1 immune response. These data suggest that vaccination with rBCG-expressing RSV Ags can induce a specific effector/memory Th1 immune response consisting on CD4(+) and CD8(+) T cells, both necessary for a fully protective response against RSV. These results support the notion that an effective induction of Th1 T cell immunity against RSV during childhood could counteract the unbalanced Th2-like immune response triggered by the natural RSV infection. The Journal of Immunology, 2010, 185: 7633-7645.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico
dc.description.funderInternational Foundation for Science
dc.description.funderVicerrectoria Adjunta de Investigacion y Doctorado-Inicio
dc.description.funderRed-15 Programa Bicentenario de Ciencia y Tecnologia
dc.description.funderMillennium Nucleus on Immunology and Immunotherapy
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4049/jimmunol.0903452
dc.identifier.eissn1550-6606
dc.identifier.issn0022-1767
dc.identifier.pubmedidMEDLINE:21084664
dc.identifier.urihttps://doi.org/10.4049/jimmunol.0903452
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79318
dc.identifier.wosidWOS:000284878700062
dc.information.autorucMedicina; Wozniak A;S/I;1008612
dc.information.autorucCiencias Biológicas;Bueno S;S/I;113541
dc.information.autorucCiencias Biológicas;Cautivo K;S/I;189036
dc.information.autorucMedicina;Cortes CM;S/I;1000888
dc.information.autorucCiencias Biológicas;Kalergis AM ;S/I;90610
dc.information.autorucCiencias Biológicas;Riedel C;S/I;88772
dc.issue.numero12
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final7645
dc.pagina.inicio7633
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.revistaJOURNAL OF IMMUNOLOGY
dc.rightsacceso restringido
dc.subjectIMMUNIZED BALB/C MICE
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectCD4+ T-CELLS
dc.subjectMHC CLASS-II
dc.subjectINTERFERON-GAMMA
dc.subjectIFN-GAMMA
dc.subjectDENDRITIC CELLS
dc.subjectRSV VACCINE
dc.subjectPULMONARY EOSINOPHILIA
dc.subjectPLASMODIUM-CHABAUDI
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEfficient Lung Recruitment of Respiratory Syncytial Virus-Specific Th1 Cells Induced by Recombinant Bacillus Calmette-Guerin Promotes Virus Clearance and Protects from Infection
dc.typeartículo
dc.volumen185
sipa.codpersvinculados1008612
sipa.codpersvinculados113541
sipa.codpersvinculados189036
sipa.codpersvinculados1000888
sipa.codpersvinculados90610
sipa.codpersvinculados88772
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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