Dentate Gyrus Somatostatin Cells are Required for Contextual Discrimination during Episodic Memory Encoding

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dc.catalogadoraba
dc.contributor.authorMorales Rojas, Cristian Enrique
dc.contributor.authorMorici, Juan Facundo
dc.contributor.authorEspinosa, Nelson
dc.contributor.authorSacson, Agostina
dc.contributor.authorLara Vásquez, Ariel Fernando
dc.contributor.authorGarcía Pérez, M. A.
dc.contributor.authorBekinschtein, Pedro
dc.contributor.authorWeisstaub, Noelia V.
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2023-10-02T16:31:43Z
dc.date.available2023-10-02T16:31:43Z
dc.date.issued2021
dc.description.abstractMemory systems ought to store and discriminate representations of similar experiences in order to efficiently guide future decisions. This problem is solved by pattern separation, implemented in the dentate gyrus (DG) by granule cells to support episodic memory formation. Pattern separation is enabled by tonic inhibitory bombardment generated by multiple GABAergic cell populations that strictly maintain low activity levels in granule cells. Somatostatin-expressing cells are one of those interneuron populations, selectively targeting the distal dendrites of granule cells, where cortical multimodal information reaches the DG. Nonetheless, somatostatin cells have very low connection probability and synaptic efficacy with both granule cells and other interneuron types. Hence, the role of somatostatin cells in DG circuitry, particularly in the context of pattern separation, remains uncertain. Here, by using optogenetic stimulation and behavioral tasks in mice, we demonstrate that somatostatin cells are required for the acquisition of both contextual and spatial overlapping memories.
dc.fechaingreso.objetodigital2023-10-02
dc.fuente.origenConveris
dc.identifier.converisid1
dc.identifier.doi10.1093/cercor/bhaa273
dc.identifier.issn1047-3211
dc.identifier.pubmedidMEDLINE:33026440
dc.identifier.scopusid2-s2.0-85100224307
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74827
dc.identifier.wosidWOS:000646868100022
dc.information.autorucEscuela de Medicina; Morales Rojas, Cristian Enrique; 0000-0003-1163-7261; 236481
dc.information.autorucEscuela de Medicina; Lara Vásquez, Ariel Fernando; S/I; 127231
dc.information.autorucEscuela de Medicina; Fuentealba, Pablo; 0000-0002-9679-4612; 19184
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1059
dc.pagina.inicio1046
dc.revistaCerebral Cortex
dc.rightsacceso restringido
dc.subjectDentate gyrus
dc.subjectHippocampus
dc.subjectInterneurons
dc.subjectMemory
dc.subjectPattern separation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDentate Gyrus Somatostatin Cells are Required for Contextual Discrimination during Episodic Memory Encoding
dc.typeartículo
dc.volumen31
sipa.codpersvinculados236481
sipa.codpersvinculados127231
sipa.codpersvinculados19184
sipa.indexWos
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadConveris;20-07-2021
sipa.trazabilidadORCID;2023-10-02
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