Multi-circuit Recording in Animal Models of Parkinson's Disease

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dc.catalogadordfo
dc.contributor.authorGarcía Núñez, Ximena Paz
dc.contributor.authorAstudillo Valenzuela, Carolina Isabel
dc.contributor.authorFuentes Flores, Rómulo Antonio
dc.date.accessioned2024-07-18T16:51:49Z
dc.date.available2024-07-18T16:51:49Z
dc.date.issued2023
dc.description.abstractOne of the main features of Parkinson’s disease is the neurodegeneration of the dopaminergic neurons of the substantia nigra pars compacta which causes a fall of the levels of dopamine in the striatum. This leads to alterations of the neural activity in all the structures of the loop circuit formed by the cortex, the basal ganglia, and thalamus. These alterations are believed to underlie the bradykinesia and hypokinesia observed in Parkinson’s disease. To study the correlation or the causality between circuitry neural activity and specific parkinsonian motor symptoms, the circuit can be interrogated by simultaneous extracellular recordings in diverse brain structures in behaving freely moving animals modeling Parkinson’s disease. Hereby, we describe the procedure to obtain the classical 6-hydroxydopamine Parkinson’s model combined with multi-area extracellular recordings in small behaving animals to access the activity of the parkinsonian cortico-basal ganglia-thalamo-cortical loop. Given that both the dopaminergic lesion caused by 6-hydroxydopamine, and the quality of the extracellular recordings have temporal dynamics of their own, the relative timing of both procedures is essential to obtain successful recording with high-quality signals.
dc.fechaingreso.objetodigital2024-09-02
dc.format.extent15 páginas
dc.identifier.doi10.1007/978-1-0716-2799-0_12
dc.identifier.isbn978-1-0716-2799-0
dc.identifier.scopusidSCOPUS_ID:85143776619
dc.identifier.urihttps://doi.org/10.1007/978-1-0716-2799-0_12
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87116
dc.information.autorucDepartamento de Ciencias de la Salud; Astudillo Valenzuela Carolina Isabel; S/I; 1094590
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final297
dc.pagina.inicio283
dc.relation.ispartofDopaminergic System Function and Dysfunction: Experimental Approaches
dc.rightsacceso restringido
dc.subject6-hydroxydopamine
dc.subjectCortex
dc.subjectElectrode array chronic implant
dc.subjectExtracellular recordings
dc.subjectParkinson’s disease
dc.subjectStriatum
dc.subjectThalamus
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMulti-circuit Recording in Animal Models of Parkinson's Disease
dc.typecapítulo de libro
sipa.codpersvinculados1094590
sipa.trazabilidadSCOPUS;02-03-2023
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