Mismatch repair expression in testicular cancer predicts recurrence and survival

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dc.contributor.authorVelasco, Alfredo
dc.contributor.authorCorvalan, Alejandro
dc.contributor.authorWistuba, Ignacio I.
dc.contributor.authorRiquelme, Erick
dc.contributor.authorChuaqui, Rodrigo
dc.contributor.authorMajerson, Alejandro
dc.contributor.authorLeach, Fredrick S.
dc.date.accessioned2024-01-10T12:40:26Z
dc.date.available2024-01-10T12:40:26Z
dc.date.issued2008
dc.description.abstractWe investigated mismatch repair (MMR) gene expression in testicular cancer as a molecular marker for clinical outcome (recurrence, response to chemotherapy and death) using protein expression and specific genetic alterations associated with the presence or absence of MMR activity. One hundred sixty-two cases of paraffin-embedded testis cancer specimens were subjected to immunohistochemical analysis using monoclonal antibody for MLH1 and MSH2 MMR proteins and genetic analysis using specific polymorphic markers. The degree of MMR immunoreactivity and genetic instability in the form of loss of heterozygosity (LOH) and/or microsatellite instability (MSI) were determined by comparing matched normal and tumor tissue. The degree of immunohistochemical staining for MMR expression was associated with a shorter time to tumor recurrence, resistance to chemotherapy and death. Furthermore, clinical relapse and cancer specific death was also associated with tumors exhibiting a high degree of MSI, p = 0.01 and 0.04, respectively. In contrast, LOH was not associated with recurrence, resistance to chemotherapy or death. Therefore, MMR expression defines testis cancers with distinct molecular properties and clinical behavior, such that tumors with decreased MMR immunostaining and/or increased frequency of MSI have a shorter time to recurrence and death despite chemotherapy. (c) 2007 Wiley-Liss, Inc.
dc.description.funderNCI NIH HHS
dc.description.funderNATIONAL CANCER INSTITUTE
dc.fechaingreso.objetodigital05-04-2024
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/ijc.23291
dc.identifier.issn0020-7136
dc.identifier.pubmedidMEDLINE:18076065
dc.identifier.urihttps://doi.org/10.1002/ijc.23291
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77309
dc.identifier.wosidWOS:000254068300014
dc.information.autorucMedicina;Chuaqui R;S/I;75420
dc.information.autorucMedicina;Corvalán A;S/I;63885
dc.information.autorucMedicina;Majerson A;S/I;148013
dc.information.autorucMedicina;Velasco A;S/I;58191
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1777
dc.pagina.inicio1774
dc.publisherWILEY-LISS
dc.revistaINTERNATIONAL JOURNAL OF CANCER
dc.rightsacceso restringido
dc.subjectmismatch repair
dc.subjecthMSH2
dc.subjecttesticular cancer
dc.subjectmicrosatellite instability
dc.subjectGERM-CELL TUMORS
dc.subjectMICROSATELLITE INSTABILITY
dc.subjectPROSTATE-CANCER
dc.subjectGENE-EXPRESSION
dc.subjectHMSH2
dc.subjectHMLH1
dc.subjectMUTATIONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMismatch repair expression in testicular cancer predicts recurrence and survival
dc.typeartículo
dc.volumen122
sipa.codpersvinculados75420
sipa.codpersvinculados63885
sipa.codpersvinculados148013
sipa.codpersvinculados58191
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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