Host-microbiome interactions in distinct subsets of preterm labor and birth

Simple item page
dc.contributor.authorGalaz, Jose
dc.contributor.authorRomero, Roberto
dc.contributor.authorGreenberg, Jonathan M.
dc.contributor.authorTheis, Kevin R.
dc.contributor.authorArenas-Hernandez, Marcia
dc.contributor.authorXu, Yi
dc.contributor.authorFarias-Jofre, Marcelo
dc.contributor.authorMiller, Derek
dc.contributor.authorKanninen, Tomi
dc.contributor.authorGarcia-Flores, Valeria
dc.contributor.authorGomez-Lopez, Nardhy
dc.date.accessioned2025-01-20T17:22:36Z
dc.date.available2025-01-20T17:22:36Z
dc.date.issued2023
dc.description.abstractPreterm birth, the leading cause of perinatal morbidity, often follows premature labor, a syndrome whose prevention remains a challenge. To better understand the relationship between premature labor and host-microbiome interactions, we conducted a mechanistic investigation using three preterm birth models. We report that intra-amniotic delivery of LPS triggers inflammatory responses in the amniotic cavity and cervico-vaginal microenvironment, causing vaginal microbiome changes and signs of active labor. Intra-amniotic IL-1 alpha delivery causes a moderate inflammatory response in the amniotic cavity but increasing inflammation in the cervico-vaginal space, leading to vaginal microbiome disruption and signs of active labor. Conversely, progesterone action blockade by RU-486 triggers local immune responses accompanying signs of active labor without altering the vaginal microbiome. Preterm labor facilitates ascension of cervico-vaginal bacteria into the amniotic cavity, regardless of stimulus. This study provides compelling mechanistic insights into the dynamic host-microbiome interactions within the cervico-vaginal microenvironment that accompany premature labor and birth.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.isci.2023.108341
dc.identifier.eissn2589-0042
dc.identifier.urihttps://doi.org/10.1016/j.isci.2023.108341
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91486
dc.identifier.wosidWOS:001114926900001
dc.issue.numero12
dc.language.isoen
dc.revistaIscience
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleHost-microbiome interactions in distinct subsets of preterm labor and birth
dc.typeartículo
dc.volumen26
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas